Sputum Neutrophil Gelatinase-Associated Lipocalin as a Biomarker in Asthma-COPD Overlap.

Background: Asthma COPD overlap (ACO) is a consensus-based phenotype having characteristics of both COPD and asthma. Distinguishing ACO from other diseases is even more important as it is related to low health-related quality of life, augmented exacerbation rate and hospital admission, a rapid deterioration in lung function, and increased morbidity and mortality. But it cannot be diagnosed explicitly based on spirometry tests, patient demographics, radiology, or by-sputum cytology.

A comparison of conventional and accelerated hypofractionated radiotherapy in definitive chemoradiation for locally advanced head and neck carcinoma: a retrospective cohort study.

Purpose: The study evaluates accelerated hypofractionated radiotherapy (AHRT) compared to conventional fractionation radiotherapy (CFRT) in patients with locally advanced head and neck cancer (LAHNC) receiving definitive chemoradiation therapy.

Materials And Methods: The study includes a retrospective cohort analysis of 120 patients. CFRT arm (n = 65) received 2 Gy per fraction to a dose of 70 Gy over 7 weeks in a three-volume approach, whereas the AHRT arm (n = 55) received 2.

May-Thurner Syndrome: A Forgotten Cause of Venous Thromboembolism.

Unlabelled: The annual incidence rates of venous thromboembolism are approximately 1 per 1,000 persons per year in adult population. Deep vein thrombosis (DVT) most frequently occurs in the setting of underlying illness, and anatomical abnormalities are rarely considered as an etiology for it. A well-described anatomical cause for DVT is "May-Thurner syndrome" (MTS), which occurs as a result of compression of the left common iliac vein by the overlying right common iliac artery.

In-silico characterization of ECE-1 inhibitors.

Atherosclerosis is the primary cause of CAD and cerebrovascular disease. Endothelin (ET)-1 is a vasoconstrictive peptide implicated in Atherosclerosis pathology. Endothelin-converting enzyme (ECE) is a membrane metalloprotease that generates endothelin.

QSAR studies on peptide alpha-ketoamides and alpha-ketohydroxamate derivatives as calpain I inhibitors.

Quantitative Structure Activity Relationship (QSAR) studies were conducted on 34 peptide alpha-ketoamide and alpha-ketohydroxamate derivatives of Calpain I using multiple linear regression (MLR) procedure. The activity contributions of these compounds were determined from regression equation and the validation procedures that analyze the predictive ability of QSAR models were described. Among forty six descriptors that were considered in generating the QSAR model, three descriptors such as LogP, Heat of formation and HOMO resulted in a statistically significant model with 0.

DoD: Database of Databases--updated molecular biology databases.

Database of Databases (DoD) is a collection of molecular biology databases extracted from Nucleic Acids Research, 2005 Database issue. DoD is constructed using javascript and html code. The 14 categories of 719 databases are provided with a search option, keyword help and database description linked to respective pages.