Information theory and thermodynamic properties for a combined potential model.

Yukawa potential and Hulthẻn potential are very useful potential models with applications in different areas of physics. The present study examined theoretic measure and thermodynamic properties of energy levels and wave functions for a combination of these two potentials. The effect of screening parameter on Fisher information and Shannon entropy as well as the effect of temperature on the various thermodynamic properties of the combined potentials and its subsets potentials are well studied.

Bioinformatics designing of an mRNA vaccine for Mokola virus (MOKV) using immunoinformatics as a secure strategy for successful vaccine development.

The Mokola Virus belongs to the family Rhabdoviridae and is genotype 3 of the Lyssavirus genera. A small number of cases of animal and human encephalomyelitis, mainly scattered over sub-Saharan Africa, have been linked to the Mokola Virus (MOKV). Currently there is no vaccine to protect against MOKV infection in people or animals.

Challenges and Recommendations for Improving Cancer Research and Practice in Nigeria: .

Background: Cancers, with increasing incidence and mortality rates, constitute a leading public health problem in Nigeria. As the burden of cancer in Nigeria increases, research and quality service delivery remain critical strategies for improved cancer control across the continuum of care. This study contextualizes the challenges and gaps in oncology research and practice in Nigeria, and presents recommendations to address the gaps.

Employing Hexahydroquinolines as CDPK4 Inhibitors to Combat Malaria Transmission: An Advanced Computational Approach.

Background: Existing antimalarial drugs primarily target blood-stage parasites, but there is a need for transmission-blocking drugs to combat malaria effectively. Calcium-dependent Protein Kinase 4 (CDPK4) is a promising target for such drugs. This study employed advanced in silico analyses of hexahydroquinolines (HHQ) derivatives to identify CDPK4 inhibitors capable of disrupting malaria transmission.

Predicting the properties of wheat flour from grains during debranning: A machine learning approach.

In the food industry, meeting food quality demands is challenging. The quality of wheat flour, one of the most commonly used ingredients, depends on the extent of debranning done to remove the aleurone layer before milling. Therefore, the end product management can be simplified by predicting the properties of wheat flour during the debranning stage.

studies of benzothiazole derivatives as potential inhibitors of and trehalase.

Introduction: In malaria management, insecticides play a crucial role in targeting disease vectors. Benzothiazole derivatives have also been reported to possess insecticidal properties, among several other properties they exhibit. The female Anopheles mosquito is responsible for transmitting the malaria parasite when infected.

Exploring computational approaches to design mRNA Vaccine against vaccinia and Mpox viruses.

Background: Messenger RNA (mRNA) vaccines emerged as a powerful tool in the fight against infections. Unlike traditional vaccines, this unique type of vaccine elicits robust and persistent innate and humoral immune response with a unique host cell-mediated pathogen gene expression and antigen presentation.

Methods: This offers a novel approach to combat poxviridae infections.

Integrating Clinical and Neuroimaging Markers to Predict the Onset of Posthemorrhagic Ventricular Dilatation in Preterm Neonates.

Background: Posthemorrhagic ventricular dilatation (PHVD) is a major complication of intraventricular hemorrhage (IVH); it is associated with high risks of cerebral palsy and cognitive deficits compared with infants without PHVD. This study aims to explore the early perinatal risk factors-associated with the risk of progressive PHVD.

Methods: Neonates ≤29 weeks gestational age (GA) with Grade II-III IVH and periventricular hemorrhagic infarct (PVHI) between 2015 and 2021 were retrospectively reviewed.

mRNA vaccine design for Epstein-Barr virus: an immunoinformatic approach.

Epstein-Barr Virus (EBV), structurally similar to other herpes viruses, possess significant global health challenges as it causes infectious mononucleosis and is also associated with various cancers. Due to this widespread impact, an effective messenger RNA (mRNA) vaccine is paramount to help curb its spread, further underscoring the need for its development. This study, following an immunoinformatic approach, aimed to design a comprehensive mRNA vaccine against the EBV by selecting antigenic proteins, predicting Linear B-cell epitopes, cytotoxic T-cell lymphocyte (CTL) and helper T-cell lymphocyte (HTL) epitopes, and assessing vaccine characteristics.

In Silico Design of Potential Small-Molecule Antibiotic Adjuvants against Ortho Acetyl Sulphydrylase Synthase to Address Antimicrobial Resistance.

The inhibition of -acetyl sulphydrylase synthase isoforms has been reported to represent a promising approach for the development of antibiotic adjuvants. This occurs via the organism developing an unpaired oxidative stress response, causing a reduction in antibiotic resistance in vegetative and swarm cell populations. This consequently increases the effectiveness of conventional antibiotics at lower doses.

Structure-based design, and development of amidinyl, amidoximyl and hydroxamic acid based organic molecules as novel antimalarial drug candidates.

Malaria remains a significant global health concern causing numerous fatalities and the emergence of antimalarial drug resistance highlights the urgent need for novel therapeutic options with innovative mechanisms of action and targets. This study aimed to design potential inhibitors of 6-pyruvoyltetrahydropterin synthase (PTPS), synthesize them, and experimentally validate their efficacy as antimalarial agents. A structure-based approach was employed to design a series of novel derivatives, including amidinyl, amidoximyl and hydroxamic acid analogs (, , , and ), with a focus on their ability to bind to the Zn present in the active site of PTPS.

National multicentered retrospective review of clinical and intraoperative factors associated with the development of cerebellar mutism after pediatric posterior fossa tumor resection.

Background: Cerebellar mutism (CM) is characterized by a significant loss of speech in children following posterior fossa (PF) surgery. The biological origin of CM remains unclear and is the subject of ongoing debate. Significant recovery from CM is less likely than previously described despite rigorous multidisciplinary neuro-rehabilitational efforts.

Synthesis, and antimicrobial efficacy of substituted arylidene-based quinazolin-4(3)-one motifs.

Quinazolin-4(3)-one derivatives have attracted considerable attention in the pharmacological profiling of therapeutic drug targets. The present article reveals the development of arylidene-based quinazolin-4(3)-one motifs as potential antimicrobial drug candidates. The synthetic pathway was initiated through thermal cyclization of acetic anhydride on anthranilic acid to produce 2-methyl-4H-3,1-benzoxazan-4-one 1, which (upon condensation with hydrazine hydrate) gave 3-amino-2-methylquinazolin-4(3)-one 2.

A genetic programming-based optimal sensor placement for greenhouse monitoring and control.

Optimal sensor location methods are crucial to realize a sensor profile that achieves pre-defined performance criteria as well as minimum cost. In recent times, indoor cultivation systems have leveraged on optimal sensor location schemes for effective monitoring at minimum cost. Although the goal of monitoring in indoor cultivation system is to facilitate efficient control, most of the previously proposed methods are ill-posed as they do not approach optimal sensor location from a control perspective.

Investigation of the possible relationship between the occurrences of atmospheric gravity waves and equatorial Spread-F.

Equatorial Spread F (ESF), is a manifestation linked to Atmospheric Gravity Waves (AGW). There have not been many studies to ascertain the extensive relationship between the occurrence of AGW and the occurrence of ESF. To evaluate the extent of their relationship, this study used data obtained with the aid of a satellite-borne Atmospheric Infrared Sounder (AIRS) and ionograms obtained using a Digisonde Portable Sounder (DPS-4) located at Jicamarca (geog.

Chemistry and Pharmacological diversity of Benzothiazepine - Excellent pathway to drug discovery.

In this era of sporadic advancement in science and technology, a substantial amount of intervention is being set in motion to reduce health-related diseases. Discoveries from researchers have pinpointed the usefulness of heterocyclic compounds, amongst which benzothiazepine (BTZ) derivatives have been synthesized for their various pharmacological activities. This also contributes to their undeniable application in therapeutic medicine for the development of efficacious drugs.

Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action.

Launaea taraxacifolia has been traditionally used for the management of conditions such as cardiovascular, respiratory, and metabolic diseases. High blood pressure was established by oral administration of L-Nitro Arginine Methyl Ester (L-NAME) a non-selective inhibitor of endothelial nitric oxide synthase (eNOS). The antihypertensive action of the methanol leaf extract of L.

Recent advances in functionalized quinoline scaffolds and hybrids-Exceptional pharmacophore in therapeutic medicine.

Quinoline is one of the most common nitrogen-containing heterocycles owing to its fascinating pharmacological properties and synthetic value in organic and pharmaceutical chemistry. Functionalization of this moiety at different positions has allowed for varying pharmacological activities of its derivative. Several publications over the last few decades have specified various methods of synthesis.

External ventricular drainage in the management of pediatric patients with posterior fossa tumors and hydrocephalus: a retrospective cohort study.

Purpose: To determine whether intraoperative adjunctive EVD placement in patients with a posterior fossa tumor (PFT) led to improved surgical, radiographic, and clinical outcomes compared to those who did not receive an EVD.

Methods: Patients were grouped as those who underwent routine intraoperative adjunctive EVD insertion and those who did not at time of PFT resection. Patients who pre-operatively required a clinically indicated EVD insertion were excluded.

Comparative Effects of Methanol and Aqueous Extracts of Corchorus olitorius Plant on Haematology and Some Reproductive Indices of Male Wistar Rats.

Corchorus olitorius is a vegetable plant/shrub and the leaves are very nutritious and rich in vitamins, minerals and dietary fibers. The study was carried out to identify the effects two extracts of this plant on the reproductive indices of male Wistar rats Forty-five adult male rats of about 12 weeks old, each weighing about 120g were used for this study, kept in a cage and fed with commercial rat pellets and water was given at ad-libitum. They were randomly divided into groups A, B and C of 15 rats per group.

Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs - a review.

Quinoline, which consists of benzene fused with -heterocyclic pyridine, has received considerable attention as a core template in drug design because of its broad spectrum of bioactivity. This review aims to present the recent advances in chemistry, medicinal potential and pharmacological applications of quinoline motifs to unveil their substantial efficacies for future drug development. Essential information in all the current and available literature used was accessed and retrieved using different search engines and databases, including Scopus, ISI Web of Knowledge, Google and PUBMED.

A primary DICER1-sarcoma with KRAS and TP53 mutations in a child with suspected ECCL.

A child had been followed since infancy by our multi-disciplinary neuro-oncology clinic with annual magnetic resonance imaging (MRI) under the presumed diagnosis of encephalocraniocutaneous lipomatosis (ECCL), with clinical features including nevus psiloliparus, scalp lipoma, nodular skin tag on and coloboma of the eyelid, cortical atrophy and meningeal angiomatosis. At the age of 4, she was found to have a large temporoparietal lesion causing elevated intracranial pressure requiring surgical resection. Histopathological exam of the tumor was suggestive of an intracranial sarcoma.

The Exploitation of Orphan Legumes for Food, Income, and Nutrition Security in Sub-Saharan Africa.

Poverty, food, and nutrition insecurity in sub-Saharan Africa (SSA) have become major concerns in recent times. The effects of climate change, drought, and unpredictable rainfall patterns threaten food production and sustainable agriculture. More so, insurgency, youth restiveness, and politico-economic instability amidst a burgeoning population requiring a sufficient and healthy diet remain front-burner issues in the region.

Spectrum of thyroid function test among type 2 diabetic patients attending a rural health facility, southwest Nigeria: A hospital-based study.

Objectives: The thyroid gland produces hormones that have significant influence on carbohydrate metabolism; its disorders may affect carbohydrate metabolism in type 2 diabetic patients (T2DM) more than the non-diabetic (NDM) patients as reported in various studies. We determined the spectrum of thyroid function tests (TFTs) profile among T2DM in our rural health facility.

Methods: T2DM patients and NDM patients were recruited for the study.