Publications by authors named "Aja Slay"
The hair follicle (HF) is a self-renewing adult miniorgan that undergoes drastic metabolic and morphological changes during precisely timed cyclic organogenesis. The HF cycle is known to be regulated by steroid hormones, growth factors and circadian clock genes. Recent data also suggest a role for a vitamin A derivative, all-trans-retinoic acid (ATRA), the activating ligand of transcription factors, retinoic acid receptors, in the regulation of the HF cycle.
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- Rexinoids, which activate nuclear receptors to regulate gene transcription, face challenges in clinical use due to side effects and unclear mechanisms across different cells.
- Treatment with the rexinoids UAB30 and UAB110 increased levels of all-trans-retinoic acid (ATRA), a key ligand for RXR-RAR complexes, in human epidermis.
- Overexpression of a dominant negative RXRα reduced the effects of these rexinoids, indicating that their biological actions depend on the RXRα activation function and could potentially normalize ATRA levels in epithelial tissues affected by certain pathologies.