Intraosseous Ganglion Protruding Into the Spinoglenoid Notch With Suprascapular Nerve Entrapment: A Case Report.

Suprascapular nerve entrapment caused by intraosseous cystic lesions is a rare condition. We present the case of a 49-year-old man with right shoulder numbness, slight infraspinatus (ISP) weakness, and shoulder pain. He underwent open surgery and arthroscopic evaluation.

Regulation of dynamic spatiotemporal inflammation by nanomaterials in spinal cord injury.

Spinal cord injury (SCI) is a common clinical condition of the central nervous system that can lead to sensory and motor impairment below the injury level or permanent loss of function in severe cases. Dynamic spatiotemporal neuroinflammation is vital to neurological recovery, which is collectively constituted by the dynamic changes in a series of inflammatory cells, including microglia, neutrophils, and astrocytes, among others. Immunomodulatory nanomaterials can readily improve the therapeutic effects and simultaneously overcome various drawbacks associated with treatment, such as the off-target side effects and loss of bioactivity of immune agents during circulation.

Do floating toes relate with the ability to perform the deep squat test among baseball players with throwing injury?

Relationship between ability to perform the deep squat test (DST) and floating toes among baseball players with disabled throwing shoulder/elbow was retrospectively investigated. Players performed the DST by fully squatting while having their arms crossed in front of their chest without lifting the heel off the floor or falling backwards. Floating toes were evaluated if all the toes were in contact with the mat or not.

Humeral Metadiaphyseal Fracture With Severe Osteoarthritis of the Shoulder and Simultaneous Contralateral Proximal Humeral Fracture Treated With Bilateral Reverse Shoulder Arthroplasty: A Rare Case Report.

Simultaneous bilateral proximal humerus fractures (PHFs) are infrequent. Particularly rare are cases of PHFs extending to the metadiaphysis accompanied by severe osteoarthritis (OA) of the shoulder. To our knowledge, there have been no reports of bilateral fractures that include metadiaphyseal fractures with severe OA on one side and a PHF on the contralateral side, treated with bilateral reverse shoulder arthroplasty (RSA).

MRTX1719, an MTA-cooperative PRMT5 Inhibitor, Induces Cell Cycle Arrest and Synergizes With Oxaliplatin and Gemcitabine for Enhanced Anticancer Effects.

Background/aim: MRTX1719 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor that targets the PRMT5-5'-Methylthioadenosine (MTA) complex called MTA-cooperative PRMT5 inhibitor. MRTX1719 acts specifically on methylthioadenosine phosphorylase (MTAP)-deficient cancer cells; however, its mechanism of action remains unclear. This study aimed to clarify the effects of MRTX1719 on the cell cycle and its synergistic effects with other anticancer drugs.

Destructive spondyloarthropathy of the lumbar spine in patients on long-term haemodialysis: a computed tomography-based study.

Purpose: Destructive spondyloarthropathy (DSA) is a serious complication of long-term haemodialysis; it commonly occurs in the cervical spine and has been investigated in cervical lesions. Although DSA of the lumbar spine has been reported, only few studies have investigated this, and the characteristics of patients with lumbar DSA are unclear. The present study aimed to elucidate the prevalence of DSA and its clinical characteristics in patients with DSA in the lumbar spine using computed tomography (CT) images of the patients who underwent lumbar spine surgery.

TiNbSn alloy plates with low Young's modulus modulates interfragmentary movement and promote osteosynthesis in rat femur.

Orthopedic implants such as arthroplasty prostheses, fracture plates, and intramedullary nails often use materials like Ti6Al4V alloy and commercially pure titanium (CP-Ti), which have Young's modulus significantly higher than that of human cortical bone, potentially causing stress shielding and inhibiting effective fracture healing. TiNbSn alloy, a β-type titanium alloy with a lower Young's modulus (40-49 GPa), has shown promise in reducing stress shielding and enhancing bone healing by promoting effective load sharing with bone. This study used 5-hole plates made from TiNbSn alloy and CP-Ti to investigate their effects on bone healing in a rat femoral fracture model.

Employee well-being in the digital age: Assessing the impacts of a smartphone application in the workplace.

Recently, providing smartphone-based health-improving applications to employees has emerged as a promising strategy for sustaining their well-being. This study estimates the impact of the routine use of an application, introduced in 2020 by a Japanese manufacturing company, on various health-related behaviours and outcomes among employees by exploiting a distinctive large-scale longitudinal dataset and personnel records. The analysis addresses potential selection biases arising from the non-random nature of application usage by employing the instrumental variable approach.

Floating Inferior Glenohumeral Ligament: A Case Report.

A humeral avulsion of the glenohumeral ligament (HAGL lesion) is a relatively rare pathology seen in patients with traumatic anterior shoulder instability. A HAGL lesion combined with a Bankart lesion is called a floating inferior glenohumeral ligament (IGHL) and is rare. We report a case of floating IGHL that could not be diagnosed before surgery.

Total Knee Arthroplasty in Patients With Ankle Osteoarthritis Affects Contralateral Ankle Alignment and Postoperative Outcome of Total Knee Arthroplasty.

Background: This study investigated the impact of total knee arthroplasty (TKA) on the alignment of the ankle joint, focusing on changes in coronal alignment of both ankles.

Methods: This retrospective study, conducted at our hospital, included 64 patients older than 70 years who underwent TKA for varus knee osteoarthritis (OA). Using full-length standing radiographs of both lower extremities taken preoperatively and 6 months postoperatively, we assessed ankle OA grading based on the Takakura-Tanaka classification and measured mechanical hip-knee-ankle (mHKA) and the tibiotalar angle (TTA) on both the surgical and contralateral side.

Impact of Aging and Knee Osteoarthritis on Lower Limb Alignment and CPAK Classification: Gender Differences in a Japanese Cohort.

This study investigates the impact of age and knee osteoarthritis (OA) on the coronal plane alignment of the lower extremity in Japanese males and females, utilizing the Coronal Plane Alignment of the Knee (CPAK) classification system. A cross-sectional analysis was conducted with 150 male and 150 female patients. Participants were divided into three groups according to age and OA progression.

Validating the Definition of Lumbar Instability-A Cross-Sectional Study with 420 Healthy Volunteers.

: Low back pain is thought to be caused by lumbar instability. To date, multiple definitions of radiological lumbar instability have been used without verifying the "normal range" of the lumbar segmental mobility. Ideally, normative data for lumbar mobility in healthy individuals are required to establish an acceptable threshold for lumbar instability.

Long-term outcome of tacrolimus-based immunosuppressive treatment for patients with paediatric-onset lupus nephritis.

Aim: We have previously reported the mid-term efficacy and safety of tacrolimus (Tac)-based immunosuppressive therapy in such patients, and herein, we aimed to determine their long-term outcomes (over 10 years).

Methods: We retrospectively evaluate the data of 13 consecutive patients with biopsy-proven long-standing LN who underwent a long-term Tac-based treatment regimen. Tac was administered once daily at a dose of 3 mg as reinduction or maintenance treatment.

Galling-Free Dry Near-Net Forging of Titanium Using Massively Carbon-Supersaturated Tool Steel Dies.

Massively carbon-supersaturated (MCSed) tool steel dies were developed to make galling-free forging products from titanium bar feedstocks in dry conditions without lubricating oils. Two types of tool steel dies were used, SKD11 and ACD56, following the Japanese Industrial Standard (JIS). The plasma-immersion carburizing process was employed to induce massive carbon supersaturation in two kinds of tool steel dies at 673 K for 14.

Multiplexed Assays of Variant Effect and Automated Patch Clamping Improve -LQTS Variant Classification and Cardiac Event Risk Stratification.

Background: Long QT syndrome is a lethal arrhythmia syndrome, frequently caused by rare loss-of-function variants in the potassium channel encoded by . Variant classification is difficult, often because of lack of functional data. Moreover, variant-based risk stratification is also complicated by heterogenous clinical data and incomplete penetrance.

Changes in the Articular Cartilage Thickness in Patients with Symptomatic Rotator Cuff Tears: A Prospective Study with a Mean 5-Year Follow-Up.

The purpose of this study was to prospectively investigate the progression of cartilage thinning in patients with symptomatic rotator cuff tears using MRI. Two hundred twenty-five consecutive patients with symptomatic rotator cuff tears visited our institute between 2009 and 2019. Of these, 28 shoulders of 27 patients (mean age, 65 years) who underwent at least two magnetic resonance imaging (MRI) examinations were prospectively enrolled.

Cut-off values of Geriatric Nutritional Risk Index for cardiovascular events in Japanese patients with acute myocardial infarction.

The Geriatric Nutritional Risk Index (GNRI) is a straightforward nutritional risk assessment tool with an established relationship with poor prognosis in patients with heart failure. However, the utility of the GNRI in patients with acute myocardial infarction (AMI) remains unclear given the time-dependent changes in the pathophysiology of AMI and the selected endpoints. Accordingly, we aimed to evaluate the optimal cut-off values of the GNRI for cardiovascular events in patients with AMI.