Improving litterfall production prediction in China under variable environmental conditions using machine learning algorithms.

Litterfall production is a major process within forest ecosystems that plays a crucial role in the global carbon cycle. Accordingly, studies have explored the abiotic and biotic features that influence litterfall production. In addition to traditional statistical models, the rapid development of nonparametric and nonlinear machine learning models, such as random forest (RF), light gradient boosting machine (LightGBM), and categorical boosting (CatBoost), have provided new methods of predicting the production of forest litterfall.

Discovery of novel phenoxybenzamide analogues as Raf/HDAC dual inhibitors.

Histone deacetylase (HDAC) inhibitors as an important epigenetic therapeutic strategy affect signaling networks and act synergistically with kinase inhibitors for the treatment of cancer. Herein we presented a series of novel phenoxybenzamide analogues with inhibition of Raf and HDAC. Among them, compound 10e showed potent antiproliferative activities against Hepg2 and MDA-MB-468 in cellular assays.

Design, synthesis and biological evaluation of novel isoindolinone derivatives as potent histone deacetylase inhibitors.

Histone deacetylases (HDACs) as appealing targets for the treatment of many diseases has been studied extensively and its use in cancer care is the most important. Here, we developed a series of novel derivatives containing isoindolinone skeleton. Twelve compounds demonstrated nanomolar IC values against HDAC1, and the best compounds were 5a (65.

Assessing the Greenhouse Gas Mitigation Potential of Harvested Wood Products Substitution in China.

Substituting harvested wood products (HWP) for greenhouse gas (GHG) intensive nonwood materials in long-lived end uses has the potential to significantly reduce GHG emissions. To determine the mitigation effects of HWP substitution, we produced China-specific wood displacement factors (DFs) by HWP end use subcategory, defined as tonnes of carbon (tC) of reduced emissions per tC contained by the HWP substituted for typical alternative nonwood materials. The weighted average DFs for substituting HWP for nonwood materials in construction and furniture production in China were estimated to be 3.