Pre-clinical methods to evaluate photic phenomena in intraocular lenses.

A new system and methodology are introduced to evaluate photic phenomena induced by different intraocular lens (IOL) technologies using a "see-through" IOL analyzer system in phakic subjects. Nineteen phakic subjects looked through the Groningen IOL Telescope type 1 (GIT1) system under different conditions. Four different IOL designs with different clinical levels of photic phenomena were evaluated by the subjects.

Optical and clinical simulated performance of a new refractive extended depth of focus intraocular lens.

Objectives: The purpose of this study is to evaluate the optical and expected clinical performance of a new refractive Extended Depth of Focus (EDF) intraocular lens (IOL), TECNIS PureSee™ IOL, designed to maintain a monofocal-like dysphotopsia profile.

Methods: Simulated visual acuity (sVA) with varying defocus was calculated using the area under the Modulation Transfer Function measured in an average eye model and from computer simulations in eye models with corneal higher-order aberrations. Tolerance to defocus was evaluated using computer simulations of the uncorrected distance sVA under defocus.

Tolerance to refractive error with a new extended depth of focus intraocular lens.

Purpose: To evaluate the tolerance to refractive errors of a new purely refractive extended depth of focus (EDF) intraocular lens (IOL), TECNIS PureSee™ IOL, using preclinical and clinical metrics.

Methods: Preclinical evaluation included computer simulations of visual acuity (sVA) and dysphotopsia profile of different IOL designs (refractive EDF, diffractive EDF, multifocal, standard, and enhanced monofocals) using an appropriate eye model with and without ±0.50 D defocus and/or +0.

Quality of vision clinical outcomes for a new fully-refractive extended depth of focus Intraocular Lens.

Background/objective: To evaluate the visual performance of a purely refractive extended depth of focus (EDF) intraocular lens (IOL).

Subjects/methods: A prospective, multi-center, randomized, subject/evaluator-masked study. Subjects were bilaterally implanted with the EDF test (Model ZEN00V, TECNIS PureSee™ IOL, N = 60) or an enhanced monofocal control (Model ICB00, TECNIS Eyhance™ IOL, N = 57) IOL.

Effect of Correcting Peripheral Refractive Errors on Retinal Sensitivity in Younger and Older Healthy Adults.

Significance: Retinal sensitivity decreases with age and age-related eye diseases. Peripheral retinal sensitivity may also be compromised if the refractive correction is not optimized for peripheral vision.

Purpose: This study aimed to determine the impact of using a peripheral refractive correction on perimetric thresholds and the influence of age and spherical equivalent on this impact.

Optical bench evaluation of the effect of pupil size in new generation monofocal intraocular lenses.

Background: A new generation of enhanced monofocal IOLs has been introduced to slightly increase the depth of focus as compared to standard monofocal IOLs. The purpose of this study is to evaluate the effect of pupil size on the through-focus optical performance of three new enhanced monofocal IOLs, designed to improve the range of vision as compared to standard monofocal IOLs.

Methods: Optical bench testing in white light was performed for different pupils, using an average cornea eye.

Effect of Violet Light-Filtering and Manufacturing Improvements in an Extended Depth-of-Focus Intraocular Lens on Visual Performance.

Purpose: To assess the experimental visual performance and dysphotopsia characteristics of the new Tecnis Symfony OptiBlue extended-depth-of-focus with violet light-filtering (ZXR00V) intraocular lens (IOL) compared with the colorless Tecnis Symfony (ZXR00) IOL.

Methods: Range of vision was assessed with simulated visual acuity defocus curves, predicted by white light through focus modulation transfer function (MTF) measurements. The clinical visual acuity defocus curve of the ZXR00 IOL was used to validate the predicted range of vision.

Clinical evaluation of a new monofocal IOL with enhanced intermediate function in patients with cataract.

Purpose: To evaluate the effectiveness and safety of 2 enhanced monofocal intraocular lenses (IOLs). The TECNIS Eyhance IOL (Model ICB00) was compared with a standard monofocal IOL (TECNIS Monofocal, Model ZCB00).

Setting: European multicenter study.

Enhancing the Intermediate Vision of Monofocal Intraocular Lenses Using a Higher Order Aspheric Optic.

Purpose: To describe and evaluate a new monofocal intraocular lens (IOL) designed to improve intermediate vision using a unique refractive technology.

Methods: The new monofocal lens is based on a higher order aspheric optic and is designed to improve intermediate vision. Simulated visual acuity from far to -2.

New algorithm for toric intraocular lens power calculation considering the posterior corneal astigmatism.

Purpose: To assess the accuracy of toric intraocular lens (IOL) power calculations of a new algorithm that incorporates the effect of posterior corneal astigmatism (PCA).

Setting: Abbott Medical Optics, Inc., Groningen, the Netherlands.

Hyperopic Q-optimized algorithms: a theoretical study on factors influencing optical quality.

In this work, we analyze the way in which pupil size, optical zone, and initial hyperopic level influence optical quality for hyperopic Q-optimized corneal refractive surgery. Different Q-optimized algorithms and the Munnerlyn formula were tested to analyze the optical quality of the final retinal image for initial hyperopic errors from 1D to 5D. Three optical zones (5.

Q-optimized Algorithms: Theoretical Analysis of Factors Influencing Visual Quality After Myopic Corneal Refractive Surgery.

Purpose: To model the effect of pupil size, optical zone, and initial myopic level on the retinal image quality after Q-optimized myopic corneal refractive surgery.

Methods: Different Q-optimized and paraxial Munnerlyn algorithms were tested using a schematic myopic eye model to analyze the optical quality of the final retinal image for initial myopic errors from -1.00 to -7.

Preclinical metrics to predict through-focus visual acuity for pseudophakic patients.

This study compares the clinical through-focus visual acuity (VA) in patients implanted with different intraocular lens (IOL) to optical bench testing of the same IOLs to evaluate the suitability of optical metrics of predicting clinical VA. Modulation transfer function and phase transfer function for different spatial frequencies and US Air Force pictures were measured using an optical bench for two monofocal IOLs, three multifocal IOLs and an extended range of vision IOL. Four preclinical metrics were calculated and compared to the clinical through-focus VA collected in three different clinical studies (243 patients in total).

The role of sensory ocular dominance on through-focus visual performance in monovision presbyopia corrections.

Monovision presbyopia interventions exploit the binocular nature of the visual system by independently manipulating the optical properties of the two eyes. It is unclear, however, how individual variations in ocular dominance affect visual function in monovision corrections. Here, we examined the impact of sensory ocular dominance on visual performance in both traditional and modified monovision presbyopic corrections.

Theoretical analysis of the effect of pupil size, initial myopic level, and optical zone on quality of vision after corneal refractive surgery.

Purpose: To analyze the theoretical effect that pupil size, optical zone, and initial myopic level have on the final retinal image after corneal refractive surgery.

Methods: A schematic myopic eye model corrected by the Munnerlyn formula was used to analyze the optical quality of the final retinal image. Root-mean-square radius spot and modulation transfer function were cal- culated by ray tracing to evaluate retinal image quality.

Quantifying age-related differences in visual-discrimination capacity: drivers with and without visual impairment.

The aim of this study is to examine the effects of aging as well as visual impairment on retinal-image quality and visual performance in drivers. We use a new visual test called Halo v1.0 software for quantifying the discrimination capacity, an important visual function for evaluating the visual disturbances perceived by the observer.

Theoretical analysis for spherical aberration induction with low-order correction in refractive surgery: comment.

In this paper, we reply to post-surgical corneal asphericity conclusions made by Dai [Appl. Opt.51, 3966 (2012)].

Designing multifocal corneal models to correct presbyopia by laser ablation.

Two multifocal corneal models and an aspheric model designed to correct presbyopia by corneal photoablation were evaluated. The design of each model was optimized to achieve the best visual quality possible for both near and distance vision. In addition, we evaluated the effect of myosis and pupil decentration on visual quality.

Visual evaluation of different multifocal corneal models for the correction of presbyopia by laser ablation.

Purpose: To evaluate the visual quality of two theoretical multifocal corneal models designed to correct presbyopia by corneal photoablation.

Methods: Two theoretical multifocal corneal surfaces were analyzed by ray tracing: a central model (with a central zone for near vision and a peripheral zone for distance vision), and a peripheral model (with a central zone for distance vision and a peripheral zone for near vision). For both models, the effect of the size of the central zone and transition zone as well as the size of the pupil was evaluated.

Visual quality after monovision correction by laser in situ keratomileusis in presbyopic patients.

Purpose: To evaluate visual quality after laser in situ keratomileusis (LASIK) performed to achieve monovision in presbyopic patients.

Setting: Laboratory of Vision Sciences and Applications, Department of Optics, University of Granada, Granada, and Clínica Novovisión, Madrid, Spain.

Design: Cohort study.