Publications by authors named "Aiwen Tan"
Cell Metab
September 2022
Article Synopsis
- * Tumor-derived factors (TDFs) were found to stimulate this trogocytosis, negatively affecting the CTLs' ability to kill tumor cells by altering their lipid profiles and decreasing levels of a protective molecule called 25-hydroxycholesterol (25HC).
- * The study showed that TDFs increase the activity of the transcription factor ATF3, which reduces the gene responsible for producing 25HC, thereby diminishing anti-tumor immunity and
