Large sample sizes are crucial for accurately capturing spatial changes in soil properties by spatial interpolation methods. However, soil bulk density (BD) data in historical datasets is often incomplete, and it's uncertain if filled values enhance spatial interpolation accuracy. Using 2,883 cropland soil BD samples from the Sichuan Basin in China, we developed the best prediction models from traditional pedotransfer function (PTF), multiple linear regression (MLR), random forest (RF), and radial basis function neural network (RBFNN) to fill missing BD values for 1,336 samples.
View Article and Find Full Text PDFArsenic trioxide (ATO) has shown substantial efficacy in the treatment of patients with acute promyelocytic leukemia, and the utilization of ATO as a potential treatment for other tumors is currently being investigated; thus, its clinical application is becoming more widespread. However, the toxicity of ATO has prevented many patients from receiving this highly beneficial treatment. The clinical features, mechanisms, and preventive measures for ATO hepatotoxicity, as well as potential curative strategies, are discussed in this review.
View Article and Find Full Text PDFAccurate cropland map serves as the cornerstone of effective agricultural monitoring. Despite the continuous enrichment of remotely sensed cropland maps, pervasive inconsistencies have impeded their further application. This issue is particularly evident in areas with limited valid observations, such as southwestern China, which is characterized by its complex topography and fragmented parcels.
View Article and Find Full Text PDFMultilayer networks composed of intralayer edges and interlayer edges are an important type of complex networks. Considering the heterogeneity of nodes and edges, it is necessary to design more reasonable and diverse community detection methods for multilayer networks. Existing research on community detection in multilayer networks mainly focuses on multiplexing networks (where the nodes are homogeneous and the edges are heterogeneous), but few studies have focused on heterogeneous multilayer networks where both nodes and edges represent different semantics.
View Article and Find Full Text PDFClimate warming can increase soil temperature and lead to soil carbon release, but it can also increase soil organic carbon by increasing primary productivity. Cropland soils are considered to have a huge potential to sequester carbon; however, direct observations for the responses of cropland soil organic carbon to climate warming over broad geographic scales are rarely documented. Paddy soil is one of the important cultivated soils in China.
View Article and Find Full Text PDFCropland soils are considered to have the potential to sequester carbon (C). Warming can increase soil organic C (SOC) by enhancing primary production, but it can also cause carbon release from soils. However, the role of warming in governing cropland SOC dynamics over broad geographic scales remains poorly understood.
View Article and Find Full Text PDFThe microstructure evolution, texture, mechanical behavior and twin deformation of the ECAPed Mg-2Y-0.6Nd-0.6Zr alloy at room and liquid nitrogen temperature were investigated by rolling samples.
View Article and Find Full Text PDFAgricultural soils have tremendous potential to sequester soil organic carbon (SOC) and mitigate global climate change. However, agricultural land use has a profound impact on SOC dynamics, and few studies have explored how agricultural land use combined with soil conditions affect SOC changes throughout the soil profile. Based on a paired soil resampling campaign in the 1980s and 2010s, this study investigated the SOC changes of the soil profile caused by agricultural land use and the correlations with parent material and topography across the Chengdu Plain of China.
View Article and Find Full Text PDFSoil acidification is a major environmental issue associated with intensive agricultural land use. Rapid urbanization has inevitably caused great changes in agricultural land use around urban areas. However, the effects of agricultural land-use change and soil parent material on the pH dynamics of the whole soil profile remain poorly understood.
View Article and Find Full Text PDFThe presence of nicotine and nicotinic acid (NA) in the marine environment has caused great harm to human health and the natural environment. Therefore, there is an urgent need to use efficient and economical methods to remove such pollutants from the environment. In this study, a nicotine and NA-degrading bacterium-strain JQ581-was isolated from sediment from the East China Sea and identified as a member of based on morphology, physio-biochemical characteristics, and 16S rDNA gene analysis.
View Article and Find Full Text PDFAll eight of the major active metabolites of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221, compound 1), an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 that has entered the clinic for the treatment of type 2 diabetes, were synthetically prepared and confirmed by comparison with samples generated in liver microsomes.
View Article and Find Full Text PDFThe bradykinin B1 receptor has been shown to mediate pain response and is rapidly induced upon injury. Blocking this receptor may provide a promising treatment for inflammation and pain. We previously reported tetralin benzyl amines as potent B1 antagonists.
View Article and Find Full Text PDFJ Med Chem
May 2008
11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) has attracted considerable attention during the past few years as a potential target for the treatment of diseases associated with metabolic syndrome. In our ongoing work on 11beta-HSD1 inhibitors, a series of new 2-amino-1,3-thiazol-4(5 H)-ones were explored. By inserting various cycloalkylamines at the 2-position and alkyl groups or spirocycloalkyl groups at the 5-position of the thiazolone, several potent 11beta-HSD1 inhibitors were identified.
View Article and Find Full Text PDFA series of 2-anilinothiazolones were prepared as inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). The most potent compounds contained a 2-chloro or 2-fluoro group on the aniline ring with an isopropyl substituent on the 5-position of the thiazolone ring (compounds 2 and 3, respectively). The binding mode was determined through the X-ray co-crystal structure of the enzyme with compound 3.
View Article and Find Full Text PDFThe bradykinin B1 receptor is induced following tissue injury and/or inflammation. Antagonists of this receptor have been studied as promising candidates for treatment of chronic pain. We have identified aryl sulfonamides containing a chiral chroman diamine moiety that are potent antagonists of the human B1 receptor.
View Article and Find Full Text PDFEfficient routes to three classes of 10-membered oxa-enediynes are presented. The electronic and stereoelectronic contributions to half-lives are supported by density functional theory calculations. One member of this class cyclizes to give an isochroman which binds to and degrades the aryl hydrocarbon receptor (AhR).
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