Publications by authors named "Aiwei Feng"
Background & Aims: Current prognostic models for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) are not extensively validated and widely accepted. We aimed to develop and validate a continuous model incorporating tumor burden and biology for individual survival prediction and risk stratification.
Methods: Overall, 4,377 treatment-naive candidates for whom TACE was recommended, from 39 centers in five countries, were enrolled and divided into training, internal validation, and two external validation datasets.
Pharmacotherapy is crucial for advanced hepatocellular carcinoma (HCC). The multi-kinase inhibitor donafenib offers superior survival benefits over sorafenib. Donafenib has first-line status, but there is limited research for combination therapies with this anticancer agent.
View Article and Find Full Text PDFPurpose: Recently, hepatic arterial infusion chemotherapy (HAIC) has also gained popularity for hepatocellular carcinoma (HCC). Several studies have compared HAIC and Transarterial chemoembolization (TACE). However, comparisons between TACE plus HAIC and HAIC are rarely reported.
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- This study aimed to identify risk factors for severe hypersensitivity reactions to oxaliplatin (OXA) during hepatic arterial infusion chemotherapy (HAIC) in gastrointestinal cancer patients.
- Out of 84 patients who experienced hypersensitivity, 27.4% had severe reactions, and a study of retreatment showed a recurrence rate of 51.9% for those with non-severe reactions.
- The analysis found that higher doses of OXA significantly increased the risk of severe reactions, highlighting the need for caution with dosing during treatment.
Article Synopsis
- - The study aimed to compare the effectiveness and safety of two chemotherapy treatments—HAI of oxaliplatin plus raltitrexed (TOMOX) and HAI of oxaliplatin plus 5-fluorouracil (FOLFOX)—for patients with unresectable colorectal cancer liver metastases (CRCLM).
- - A total of 113 patients were randomly assigned to receive either TOMOX or FOLFOX, with primary endpoints focusing on progression-free survival (PFS) and objective response rate (ORR), while secondary endpoints included overall survival (OS) and adverse events.
- - Results showed no significant difference between the two treatments in terms of PFS (5.8 months for
Objective: Hepatic arterial infusion chemotherapy (HAIC) is an effective treatment for advanced unresectable colorectal cancer liver metastases (CRLM). This study was conducted to predict the efficacy of HAIC in patients with unresectable CRLM by radiomics methods based on pretreatment computed tomography (CT) examinations and clinical data.
Materials And Methods: A total of 63 patients were included in this study (41 in the training group and 22 in the validation group).
Aims: This study aims to observe the preliminary clinical efficacy of percutaneous interstitial brachytherapy using iodine-125 seeds for the treatment of advanced malignant lung tumors.
Subjects And Methods: This retrospective study enrolled 24 patients in our hospital with advanced malignant lung tumors between June 2013 and November 2017. Computed tomography (CT)-guided iodine-125 seed implantation therapy was administered to these patients.