Publications by authors named "Aitao Wang"
Article Synopsis
- Previous studies showed that Calycosin (CA) helps with spinal cord injury (SCI), and this study investigates its role in promoting axon growth.
- Researchers created an SCI model in rats and a lab model using chondroitin sulfate proteoglycan (CSPG) to examine how CA affects axon regeneration.
- CA treatment enhanced the growth of nerve cells and increased the levels of specific markers associated with axon regeneration, while also regulating the expression of a direct target protein called PTPRS.
Article Synopsis
- Radiofrequency thermocoagulation (RFT) is a common treatment for thoracic post-herpetic neuralgia (PHN), but it has issues such as inadequate pain relief and postoperative skin numbness.
- A study compared the outcomes of low-temperature plasma coblation to RFT for treating refractory PHN, finding promising results for coblation in terms of pain management.
- The matched-cohort study revealed that patients treated with coblation reported significantly better pain scores at six and twenty-four months compared to those who had RFT, suggesting coblation might be a more effective option.
Article Synopsis
- Radiofrequency thermocoagulation (RFT) is an effective treatment for idiopathic trigeminal neuralgia (ITN) but can lead to postoperative facial numbness due to damage to both pain and tactile fibers during the procedure.
- A study analyzed data from 72 ITN patients who underwent RFT, comparing those with low sensory stimulation voltage (SV) to those with high SV, finding significant differences in levels of facial numbness post-surgery.
- Results showed that higher SV resulted in lower rates of moderate facial numbness and better overall outcomes, suggesting that SV is an important factor in reducing postoperative complications.
Article Synopsis
- The study investigates the effects of SBG on bone cancer pain (BCP) and aims to clarify its underlying mechanisms.
- Researchers used databases to identify active compounds in SBG and relevant cancer targets, and they created network diagrams to analyze these connections.
- The main active components, baicalein and wogonin, were found to interact with important targets, suggesting potential pathways through which SBG may alleviate BCP.
Article Synopsis
- Zhenbao pill, particularly its main component calycosin, shows promise in protecting against spinal cord injury (SCI) by targeting oxidative stress and cell apoptosis.
- In experiments, calycosin reversed the harmful effects of SCI, including elevated reactive oxygen species (ROS) and malondialdehyde (MDA), while enhancing important protective proteins like superoxide dismutase (SOD) and heat shock protein 90 (HSP90).
- Calycosin treatment not only improved motor function in rats with SCI but also indicated a potential mechanism of action involving the regulation of protein kinase B (Akt) and apoptosis signal-regulating kinase 1 (ASK1).
Article Synopsis
- Baicalin, a flavonoid with antioxidant and pain-relieving properties, was studied for its effects on bone cancer pain in a rat model.
- The study showed that baicalin treatment reduced osteoclast activation and inflammatory factors associated with bone metastases.
- Findings suggest that baicalin may offer a potential therapeutic approach for managing bone pain linked to breast cancer.
Article Synopsis
- Bone cancer pain (BCP) is prevalent in cancer patients and is linked to the activation of microglia cells, which contribute to pain.
- A compound called BAM8-22 has been shown to relieve BCP by inhibiting this microglial activation, although the specific mechanism was previously unclear.
- This study found that BAM8-22 increases levels of the molecule miR-184, which binds to CX3CR1 and reduces microglial activation and inflammatory responses, indicating potential therapeutic targets for treating BCP.
Article Synopsis
- The study aimed to investigate the role of the nuclear pore membrane protein POM121 in oral squamous cell carcinoma (OSCC) and its underlying mechanisms.
- Results showed that POM121 mRNA and protein levels were significantly higher in OSCC tissues than in normal tissues, with high expression linked to worse patient survival and advanced disease stages.
- Bioinformatics suggested that POM121 may influence OSCC via the hedgehog and/or p53 signaling pathways, indicating that targeting POM121 could lead to new diagnostic and treatment options.
Article Synopsis
- Dexmedetomidine (DEX) is a sedative that also shows potential anti-inflammatory properties, particularly in the context of acute liver injury.
- In a study, mice were injected with substances to induce liver injury, and DEX was administered either before or after exposure. Findings indicated that pre-treatment with DEX significantly reduced liver damage and improved survival rates.
- The study suggests that DEX helps minimize inflammation by inhibiting harmful proteins and processes associated with liver cell death, indicating potential protective benefits against inflammatory liver diseases.
Article Synopsis
- Fractalkine is implicated in increasing pain sensitivity and hyperalgesia by activating microglia through the CX3CR1 receptor, which releases pro-inflammatory cytokines.
- Researchers investigated the role of calcium signaling (specifically IP3) in this process using BV-2 cells and a mouse model to observe fractalkine's effects in the brain.
- Results showed that fractalkine elevated calcium levels and pro-inflammatory markers in microglia, while blocking its action reduced pain sensitivity, indicating that fractalkine may contribute to hyperalgesia through calcium signaling pathways.
Lipoxin A4 inhibits the production of proinflammatory cytokines induced by β-amyloid in vitro and in vivo.
Biochem Biophys Res Commun
May 2011
Article Synopsis
- Research shows that inflammation caused by β-amyloid (Aβ) plays a significant role in Alzheimer's disease progression, prompting studies on how to reduce this inflammation.
- This study focused on the effects of lipoxin A(4) (LXA(4)), which was found to lower the levels of the inflammatory molecules IL-1β and TNFα in mouse brain regions affected by Aβ.
- LXA(4) achieved this by inhibiting key signaling processes, specifically the NF-κB pathway, thereby preventing the inflammatory response caused by β-amyloid.