A Novel Combinatorial Regimen Using Sorafenib and Uttroside B, A US FDA-designated 'Orphan Drug', for the Treatment of Hepatocellular Carcinoma.

Introduction: Sorafenib (Sor) is the first-line treatment option in clinics for treating advanced unresectable hepatocellular carcinoma (HCC). However, acquired chemoresistance and adverse side effects associated with Sor monotherapy limit its clinical benefits. We have previously reported the exceptional anti-HCC potential of uttroside B (Utt-B), a furostanol saponin isolated in our lab from Linn.

Comparative evaluation of the efficacy of Triphala mouthwash and Curcumin mouthwash in the treatment of gingivitis - A randomized controlled study.

Background: Numerous studies on Triphala and Curcumin mouthwashes were analyzed individually and no study has compared the efficacy of Triphala mouthwash to Curcumin mouthwash in the management of gingivitis. Although various mouthwashes have shown reduction of plaque and gingivitis the search is still on for an ideal mouthwash with minimum side effects and better patient acceptance.

Objectives: To access the efficacy of all the mouthwashes in the management of gingivitis.

Corrigendum: Targeting thymidylate synthase enhances the chemosensitivity of triple-negative breast cancer towards 5-FU-based combinatorial therapy.

[This corrects the article DOI: 10.3389/fonc.2021.

Targeting receptor tyrosine kinase signaling: Avenues in the management of cutaneous squamous cell carcinoma.

Non-melanoma skin cancer (NMSC) is the most frequently diagnosed cancer worldwide. Among the various types of NMSCs, cutaneous squamous cell carcinoma (cSCC) exhibits more aggressive phenotype and is also the second-most prevalent type. Receptor tyrosine kinases (RTK) triggers key signaling events that play critical roles in the development of various cancers including cSCC.

A potent bioactive fraction against colon cancer from .

Aim: This study was designed to investigate the anticancer efficacy of the organic leaf extracts of the plant, (), and to analyze the molecular mechanism of the anticancer activity.

Methods: The leaf extracts were prepared by polarity-graded serial extraction of the dried leaf powder. The cytotoxic effect of the extracts was analyzed by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay.

Corrigendum: Blockade of uttroside B-induced autophagic pro-survival signals augments its chemotherapeutic efficacy against hepatocellular carcinoma.

[This corrects the article DOI: 10.3389/fonc.2022.

Corrigendum: Cucurbitacin B, purified and characterized from the rhizome of exhibits anti-melanoma potential.

[This corrects the article DOI: 10.3389/fonc.2022.

Pharmacological attenuation of melanoma by tryptanthrin pertains to the suppression of MITF-M through MEK/ERK signaling axis.

Melanoma is the most aggressive among all types of skin cancers. The current strategies against melanoma utilize BRAF, as a focal point for targeted therapy. However, therapy resistance developed in melanoma patients against the conventional anti-melanoma drugs hinders the ultimate benefits of targeted therapies.

Cucurbitacin B, Purified and Characterized From the Rhizome of Exhibits Anti-Melanoma Potential.

The ethnomedicinal plant from the Cucurbitaceae family, , or its bioactive derivatives have been widely utilized in traditional medicine owing to their distinct applications against various human ailments and have lured the interest of ethnobotanists and biochemists. Here, we report for the first time, the anti-cancer potential of a bio-active fraction isolated from the dried rhizome of , and the bioactive principle identified as cucurbitacin B (Cu-B). The purification processes involving the utilization of multiple organic extracts of rhizome powder, yielded Cu-B from the Ethyl acetate Cytotoxic Fraction (ECF), obtained by the chromatographic separation of the ethyl acetate extract.

Recent Advances in Peptides-Based Stimuli-Responsive Materials for Biomedical and Therapeutic Applications: A Review.

Smart materials are engineered materials that have one or more properties that are introduced in a controlled fashion by surrounding stimuli. Engineering of biomacromolecules like proteins into a smart material call for meticulous artistry. Peptides have grabbed notable attention as a preferred source for smart materials in the medicinal field, promoted by their versatile chemical and biophysical attributes of biocompatibility, and biodegradability.

A novel and effective technique to reduce electromagnetic radiation absorption on biotic components at 2.45 GHz.

A strong evidence of the effects of radiation absorption on the living community together with a better solution to reduce the radiation intensity without compromising the usage of wireless communication systems is presented. This study analyses the radiation effects on living things and validates the proposed techniques for specific absorption rate (SAR) value reduction at 2.45 GHz.

Blockade of Uttroside B-Induced Autophagic Pro-Survival Signals Augments Its Chemotherapeutic Efficacy Against Hepatocellular Carcinoma.

Our previous study has demonstrated that Uttroside B (Utt-B), a saponin isolated from the leaves of Linn induces apoptosis in hepatic cancer cells and exhibits a remarkable growth inhibition of Hepatocellular Carcinoma (HCC). Our innovation has been granted a patent from the US (US 2019/0160088A1), Canada (3,026,426.), Japan (JP2019520425) and South Korea (KR1020190008323) and the technology have been transferred commercially to Q Biomed, a leading US-based Biotech company.

Development of a Microwave Sensor for Solid and Liquid Substances Based on Closed Loop Resonator.

In this work, a compact dielectric sensor for the detection of adulteration in solid and liquid samples using planar resonators is presented. Six types of filter prototypes operating at 2.4 GHz are presented, optimized, numerically assessed, fabricated and experimentally validated.

Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy.

Background: The ongoing treatment modalities for breast cancer (BC) primarily rely on the expression status of ER, PR and HER-2 receptors in BC tissues. Our strategy of chemosensitization provides new insights to counter chemoresistance, a major obstacle that limits the benefits of chemotherapy of mammary cancers.

Methods: By utilizing a murine breast cancer model employing NSG mice bearing orthotopic triple-negative breast cancer (TNBC) xenografts, we have evaluated the ability of phytochemical curcumin in chemosensitizing BC to 5-Fluorouracil (5-FU) chemotherapy and the differential modulations of cellular events in response to this strategy, independent of their receptor status.

Students' perception and preference for online education in India during COVID -19 pandemic.

Educational institutes across the world have closed due to the COVID-19 pandemic jeopardizing the academic calendars. Most educational institutes have shifted to online learning platforms to keep the academic activities going. However, the questions about the preparedness, designing and effectiveness of e-learning is still not clearly understood, particularly for a developing country like India, where the technical constraints like suitability of devices and bandwidth availability poses a serious challenge.

Compositional variation in the leaf, mace, kernel, and seed essential oil of nutmeg ( Houtt.) from the Western Ghats, India.

The essential oil (EO) from leaf, mace, kernel, and seed of Houtt. growing in the Western Ghats, India was investigated for the first time. The EO was extracted by hydrodistillation and analysed by GC-MS.

Diallel Analysis of Chilli Pepper ( L.) Genotypes for Morphological and Fruit Biochemical Traits.

Chilli pepper is commercially cultivated as a spice and is also used for the extraction of a colouring agent. Here, we performed a diallel genetic study involving five chilli pepper varieties. Parents and their hybrid were evaluated for fifteen morphological and five biochemical traits over two crop seasons under open field conditions.