Publications by authors named "Aishwarya Vetrivel"

Context: Staphylococcus aureus is a highly pathogenic organism that is the most common cause of postoperative complications as well as severe infections like bacteremia and infective endocarditis. By mediating the formation of biofilms and the expression of virulent genes, the quorum sensing (QS) mechanism is a major contributor to the development of these diseases. By hindering its QS network, an innovative approach to avoiding this bacterial infection is taken.

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The quorum sensing network of Pseudomonas aeruginosa mediates the regulation of genes controlling biofilm formation and virulence factors. The rise of drug resistance to Pseudomonas aeruginosa infections has made quorum sensing-regulated biofilm formation in clinical settings a major issue. In the present study, LasR inhibitors identified in our previous study were evaluated for their antibiofilm and antiquorum sensing activities against P.

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, a virulent pathogen affects patients with cystic fibrosis and nosocomial infections. Quorum sensing (QS) mechanism plays a crucial role in causing these ailments by mediating biofilm formation and expressing virulent genes. A novel approach to circumvent this bacterial infection is by hindering its QS network.

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Article Synopsis
  • The bacterium in focus is a serious threat to cystic fibrosis patients and those with weakened immune systems, causing about 1000 deaths yearly due to its ability to form biofilms and resist antibiotics.
  • Quorum sensing, particularly through the LasR protein, regulates virulence and biofilm formation, making it a prime target for new treatments.
  • This study used advanced computational methods to discover new LasR inhibitors, identifying three promising compounds that showed stability and effectiveness in reducing virulence in lab tests.
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