Polyherbal formulation PL02 alleviates pain, inflammation, and subchondral bone deterioration in an osteoarthritis rodent model.

Introduction: Osteoarthritis (OA) is a debilitating disease with significant personal and socioeconomic burdens worldwide.

Methods: To address this, we developed a multitargeted formulation called PL02, which includes standardized extracts of L, , and collagen peptide. We tested the pharmacological efficacy of PL02 in a rodent model of OA induced by Monosodium iodoacetate (MIA).