Publications by authors named "Aishwarya Sen"
Article Synopsis
- Dendritic cells (DCs) can quickly change their metabolism to create immune responses, and researchers discovered that removing NCoR1 leads to DCs that promote immune tolerance by increasing the production of key cytokines like IL-10 and IL-27.!* -
- These tolerogenic DCs use enhanced glycolysis and oxidative phosphorylation to meet energy needs, while reduced metabolism of pyruvate and glutamine helps maintain their tolerant state.!* -
- Inhibiting specific metabolic pathways with drugs affected the ability of these DCs to support tolerant responses, shifting T helper cell polarization and reducing bacterial infection levels in a tuberculosis model, highlighting the significant role of NCoR1 in immune regulation.!*
Tight control of gene regulation in dendritic cells (DCs) is important to mount pathogen specific immune responses. Apart from transcription factor binding, dynamic regulation of enhancer activity through global transcriptional repressors like Nuclear Receptor Co-repressor 1 (NCoR1) plays a major role in fine-tuning of DC responses. However, how NCoR1 regulates enhancer activity and gene expression in individual or multiple Toll-like receptor (TLR) activation in DCs is largely unknown.
View Article and Find Full Text PDF