Publications by authors named "Aishwarya Ghosh"

Alterations in Heart Rate (HR) and Heart Rate Variability (HRV) reflect autonomic dysfunction associated with neurodegeneration making them biomarkers suitable for detecting Mild Cognitive Impairment (MCI). The study involves 297 urban Indian participants [48.48% (144) were male and 51.

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Recent studies have shown that in some reasoning tasks people with Autism Spectrum Disorder perform better than typically developing people. This paper compares four such tasks, namely a syllogistic task, two decision-making tasks, and a task from the heuristics and biases literature, the aim being to identify common structure as well as differences. In the terminology of David Marr's three levels of cognitive systems, the tasks show commonalities on the computational level in terms of the effect of contextual stimuli, though an in-depth analysis of such contexts provides certain distinguishing features in the algorithmic level.

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Vitamin D (VitD) is a naturally occurring, fat-soluble vitamin which regulates calcium and phosphate homeostasis in the human body and is also known to have a neuroprotective role. VitD deficiency has often been associated with impaired cognition and a higher risk of dementia. In this study, we aimed to explore the relationship between levels of VitD and cognitive functioning in adult individuals.

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Objectives: Aging is a natural process and is often associated with an increased incidence of cognitive impairment. Physical exercise, diet, and leisure activities (music, dance, and art) are some of the lifestyle factors that contribute to healthy aging. The present study aims to explore the differences in cognitive functioning between aging individuals involved in musical activity throughout their lifetime and the ones who were not.

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Article Synopsis
  • The rise in dementia, particularly Alzheimer’s disease (AD), necessitates a deeper understanding of its causes and treatments to enhance patient and caregiver quality of life.
  • AD’s pathophysiology involves the buildup of amyloid-beta plaques and tau protein abnormalities, leading to neurotransmitter imbalances that affect brain function.
  • FDA-approved treatments for AD can be divided into those addressing behavioral symptoms (like brexpiprazole for agitation) and cognitive decline (such as donepezil, a commonly prescribed cholinesterase inhibitor), each with specific mechanisms and side effects that require monitoring.
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Bacterial ribonucleoprotein bodies (BR-bodies) are non-membrane-bound structures that facilitate mRNA decay by concentrating mRNA substrates with RNase E and the associated RNA degradosome machinery. However, the full complement of proteins enriched in BR-bodies has not been defined. Here, we define the protein components of BR-bodies through enrichment of the bodies followed by mass spectrometry-based proteomic analysis.

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The initiation of translation in bacteria is thought to occur upon base pairing between the Shine-Dalgarno (SD) site in the mRNA and the anti-SD site in the rRNA. However, in many bacterial species, such as Caulobacter crescentus, a minority of mRNAs have SD sites. To examine the functional importance of SD sites in C.

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