lncRNA‑MALAT1 promotes high glucose‑induced H9C2 cardiomyocyte pyroptosis by downregulating miR‑141‑3p expression.

Diabetic cardiomyopathy (DCM) is caused by diabetes and can result in heart failure. Long non‑coding RNAs (lncRNAs) have been demonstrated to be closely associated with DCM development. The present study aimed to investigate whether lncRNA‑metastasis‑associated lung adenocarcinoma transcript‑1 (MALAT1) altered high glucose (HG)‑induced H9C2 cardiomyocyte pyroptosis by targeting microRNA (miR)‑141‑3p.

[Prevention of rupture of atherosclerotic plaque by Candesartan in rabbit model].

Objective: To evaluate Candesartan therapeutic effect against atherosclerotic plaque rupture and to explore the related mechanisms.

Methods: Thirty-four New Zealand White male rabbits were randomly divided into three groups: the control group, the model control group and the Candesartan intervention group. The control group rabbits were fed with a normal diet.