Developing novel hybrid bilayer nanofibers based on polylactic acid with impregnation of chamomile essential oil and gallic acid-stabilized silver nanoparticles.

This study presents fabrication and characterization of novel chamomile essential oil (CMO)/gallic acid-stabilized silver nanoparticles (gallic acid-nanosilver, GNS), embedded into polylactic acid (PLA)-based hybrid bilayer nanofibers (NFs). Where CMO was impregnated into polyvinyl alcohol (PVA)-polyethylene glycol (PEG) solution and electrospun simultaneously with PLA to obtain PLA/PVA-PEG-CMO NFs (PLA/CMO A2). Meanwhile, GNS were added to PVA-PEG-CMO and electrospun to obtain PLA/PVA-PEG-CMO-GNS NFs (PLA/CMO-GNS A3).

Biosynthesis and biological activities of magnesium hydroxide nanoparticles using Tinospora cordifolia leaf extract.

The synthesis of magnesium hydroxide nanoparticles (Mg(OH) NPs) using plant extracts are known to be a practical, economical, and an environmentally friendly approach. In this work, Mg(OH) NPs were synthesized using aqueous leaf extract of Tinospora cordifolia, a medicinal plant commonly found in India. The synthesized Mg(OH) NPs were characterized using various spectroscopic techniques.

Unveiling the diverse bioactivity of cobalt oxide nanoparticles produced through carboxymethyl cellulose extraction.

This study explores an eco-friendly method for synthesizing Cobalt oxide nanoparticles (CoONPs) using extracted carboxymethyl cellulose (CMC) as a reducing and stabilizing agent. The CoONPs, characterized via various analyses, demonstrated a crystalline structure with sizes ranging from 10.9 to 28.

Zinc oxide nanoparticles loaded with linalool as a potential control agent of malaria infection.

This research aimed to produce and analyze zinc oxide nanoparticles (ZNPs) loaded with linalool (LZNPs), and to evaluate their in vitro and in vivo efficacy through targeting the inflammation and oxidative stress. LZNPs were synthesized using an ethanolic solution of polyvinyl alcohol. The Malstat technique was used to evaluate the effectiveness of LZNPs against both sensitive and resistant strains of Plasmosium falciparum.

High potency of linalool-zinc oxide nanocomposite as a new agent for cystic echinococcosis treatment.

This current , , and research aims to evaluate and analyze the linalool-zinc oxide nanocomposite (Lin-ZNP) for treating cystic echinococcosis. Lin-ZNP was synthesized using an ethanolic solution of polyvinyl alcohol. The protoscolicidal effects of Lin-ZNP were tested on hydatid cyst protoscoleces (PTS) in both and by eosin exclusion test.

Linalool-zinc oxide nanocomposite controls Toxoplasma gondii infection through inhibiting inflammation, oxidative stress, and pathogenicity.

The present in vitro and in vivo study aimed to fabricate and characterize linalool-zinc oxide nanoparticles (Lin-ZNP) and evaluate their effectiveness against Toxoplasma gondii infection in terms of inflammation, oxidative stress, and pathogenicity. Lin-ZNP was synthesized using an ethanolic solution of polyvinyl alcohol. The anti-Toxoplasma and cytotoxicity activities of Lin-ZNP were investigated, along with its effects on nitric oxide (NO) production, caspase-3 activity, and pro-inflammatory genes.

Immunomodulatory effects of Kaempferol on microglial and Macrophage cells during the progression of diabetic retinopathy.

Background: Diabetic retinopathy (DR) stands as a prevalent secondary complication of diabetes, notably Type 1 Diabetes Mellitus (T1D), characterized by immune system involvement potentially impacting the retinal immune response mediated by microglia. Early stages of DR witness blood-retinal barrier permeabilization, facilitating peripheral immune cell interaction with the retinal immune system. Kaempferol (Kae), known for its potent anti-inflammatory activity, presents a promising avenue in DR treatment by targeting the immune mechanisms underlying its onset and progression.

Unveiling of the antileishmanial activities of Linalool loaded zinc oxide nanocomposite through its potent antioxidant and immunomodulatory effects.

This study aimed to produce linalool loaded zinc oxide nanocomposite (LZNPs) and assess its in vitro and in vivo antileishmanial effects against Leishmania major. LZNPs was produced through the synthesis of an ethanolic solution containing polyvinyl alcohol. The average size of LZNPs was determined to be 105 nm.

Effect of Five Different Antioxidants on the Effectiveness of Goat Semen Cryopreservation.

The effective combination of semen cryopreservation and artificial insemination has a positive effect on the conservation of germplasm resources, production and breeding, etc. However, during the process of semen cryopreservation, the sperm cells are very susceptible to different degrees of physical, chemical, and oxidative stress damage. Oxidative damage is the most important factor that reduces semen quality, which is affected by factors such as dilution equilibrium, change of osmotic pressure, cold shock, and enzyme action during the freezing-thawing process, which results in the aggregation of a large amount of reactive oxygen species (ROS) in sperm cells and affects the quality of semen after thawing.

Targeted Drug Administration onto Cancer Cells Using Hyaluronic Acid-Quercetin-Conjugated Silver Nanoparticles.

Quercetin (QtN) displays low systemic bioavailability caused by poor water solubility and instability. Consequently, it exerts limited anticancer action in vivo. One solution to increase the anticancer efficacy of QtN is the use of appropriate functionalized nanocarriers that preferentially target and deliver the drug to the tumor location.

Dual Studies of Photo Degradation and Adsorptions of Congo Red in Wastewater on Graphene-Copper Oxide Heterostructures.

This work comprehensively studies both the photocatalytic degradation and the adsorption process of Congo red dye on the surface of a mixed-phase copper oxide-graphene heterostructure nanocomposite. Laser-induced pristine graphene and graphene doped with different CuO concentrations were used to study these effects. Raman spectra showed a shift in the D and G bands of the graphene due to incorporating copper phases into the laser-induced graphene.

Antiapoptotic Gene Genotype and Allele Variations and the Risk of Lymphoma.

Background: The findings of earlier investigations of antiapoptotic gene genotypes and allele variants on lymphoma risk are ambiguous. This study aimed to examine the relationship between the mutation in the antiapoptotic genes and lymphoma risk among Saudi patients.

Methods: This case-control study included 205 patients, 100 of whom had lymphoma (cases) and 105 who were healthy volunteers (controls).

The curative and mechanistic acumen of curcuminoids formulations against haloperidol induced Parkinson's disease animal model.

Parkinson's disease (PD) is slowly developing neurodegenerative disorder associated with gradual decline in cerebration and laboriousness to perform routine piece of work. PD imposed a social burden on society through higher medical cost and by loss of social productivity in current era. The available treatment options are expensive and associated with serious adverse effect after long term use.

Relationship between KIR genotypes and HLA-ligands with SARS-CoV-2 infection in the Saudi population.

Aim: To ascertain whether killer cell immunoglobulin-like receptors (KIR) genes polymorphisms and HLA-I ligands are associated with COVID-19 in Saudi Arabia.

Methods: Eighty-seven COVID-19 patients who tested positive for SARS-CoV-2 and one hundred and fourteen healthy controls were enrolled in this study for genotyping of the 16 KIR genes, HLA-C1 and -C2 allotypes and HLA-G 14-bp indels polymorphisms using the sequence specific primer polymerase chain reaction (SSP-PCR) method. KIR genotype frequency differences and combination KIR-HLA-C ligand were tested for significance.

Ethnomedicinal Plants with Protective Effects against Beta-Amyloid Peptide (Aβ)1-42 Indicate Therapeutic Potential in a New In Vivo Model of Alzheimer's Disease.

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with unmet medical need. This investigation consisted of testing a range of ethanolic ethnomedicinal plant extracts (n = 18) traditionally used in the treatment of disorders such as anxiety, delirium, and memory loss. They were then screened for in vitro inhibitory activity against acetylcholinesterase (AChE), butylcholinesterase (BuChE), beta-secretase 1/beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), and antioxidant activities.

Diosgenin Modulates Oxidative Stress and Inflammation in High-Fat Diet-Induced Obesity in Mice.

Introduction: Obesity is a chronic metabolic disorder that results in excessive energy accumulated in adipose tissue causing dysfunction of adipocytes, inflammation, and oxidative stress. Diosgenin (DG), a steroidal saponin produced by several plants, has been reported to have antioxidant activity. This study aimed to evaluate the effects of diosgenin on oxidative stress and inflammation in mice fed with a high-fat diet (HFD).

Response of Growth, Yield, and Phytochemical Behavior of Jojoba Genotypes to Plant Extract.

A unique storage lipid wax found in jojoba seeds can be employed as a chemical feedstock. Alternative safe and natural sources of plant nutrients are constantly sought to preserve both human health and the environment. As a result, EAI1, EAI2, and EAI3 jojoba genotypes' growth, yield, and phytochemical behavior in response to Azolla extract at concentrations of 0, 10, and 30% were studied.

Impact of planting density and soaking seeds in melatonin solution on yield, secondary products content and antimicrobial activity of lovage plant.

Many studies worldwide have been done on the effect of medicinal uses of lovage plant but, very little works have been done on its production. In this study the effect of different planting density and soaking seeds in different concentration of melatonin solution as well as their combination treatments on yield, secondary products content and antimicrobial activity of lovage plant were studied. It was observed that using planting space of 15 cm gave the maximum mean values of total phenolic and antioxidant content and essential oil percentage.

Antitumor Activity of Royal Jelly and Its Cellular Mechanisms against Ehrlich Solid Tumor in Mice.

Objective: The present study was aimed at evaluating the antitumor effects of royal jelly (RJ) obtained from compared with cyclophosphamide against the Ehrlich solid tumors (EST) in mice.

Methods: Tumor growth inhibition, body weight, the serum level of alpha-fetoprotein (AFP) and carcinoembryonic antigen tumor (CAE), liver and kidney enzymes, tumor lipid peroxidation (LPO), nitric oxide (NO), antioxidant enzymes (glutathione peroxidase (GPx), catalase enzyme (CAT), and superoxide dismutase enzyme activity (SOD)), tumor necrosis factor alpha level (TNF-), and the apoptosis-regulatory genes expression were assessed in EST mice treated with RJ (200 and 400 mg/kg orally once a day for 2 weeks).

Results: The results showed that treatment of EST-suffering mice with RJ at the doses of 200 and 400 mg/kg causes significant reduction in tumor volume and inhibition rate, body weight, tumor markers (AFP and CEA), serum level of liver and kidney, LPO and NO, TNF- level, as well as the expression level of Bcl-2 in comparison with the EST mice receiving the normal saline; whereas RJ at the doses of 200 and 400 mg/kg/day significantly increased ( < 0.

Green Silver Nanoparticles Synthesized from Elicits Effective Anti-Diabetic Effect in Alloxan-Induced Diabetic Wistar Rats.

Using a variety of chemical compounds and biomolecules, researchers have been working on new antidiabetic drugs for many years. Anti-diabetic research is increasingly using nanomaterials because of their unique qualities, such as their tiny size, biocompatibility, and ability to penetrate cell membranes for drug delivery. Using extract of coated with silver nanoparticles as a model for diabetes mellitus research was one of the goals of this work.

Antidepressant activity of phytochemicals of Mangifera indica seeds assisted by integrated computational analysis.

Mangifera indica L., also known as mango, is a tropical fruit that belongs to the Anacardiaceae family and is prized for its juiciness, unique flavour, and worldwide popularity. The current study aimed to probe into antidepressant power (ADP) of MIS in animals and confirmation of ADP with in silico induced-fit molecular docking.

Designing of modified ion-imprinted chitosan particles for selective removal of mercury (II) ions.

Ion-imprinting methodology was utilized in the fabrication of mercury ion-imprinted sorbent derived from modified chitosan derivatives. The Schiff base ligand was first derived from 4-amino-3-hydroxybenzoic acid and 2-pyridinecarboxaldehyde (HPB) and then incorporated with chitosan via amide bonds. The obtained modified chitosan polymeric ligand (PBCS) was combined with Hg(II) ions to produce the corresponding polymeric complex and the imprinting was then achieved upon the glutaraldehyde cross-linking and eliminating the incorporated Hg(II) ions to finally have the Hg(II) ion-imprinted sorbent material (Hg-PBCS).

Maximizing Leaves, Inflorescences, and Chemical Composition Production of Trees under Calcareous Soil Conditions.

One of the main issues limiting plant productivity is a lack of soil nutrient resources, especially in calcareous soil, which covers more than one third of the world's land surface area. On the other hand, despite rising demand for all parts of the tree, several studies have focused on its leaf production as an herbaceous plant, rather than as a tree, and no extensive research has been carried out on leaf and inflorescence production in the mature tree. As a result, the influence of vermicompost and NPK (minerals and nanoparticles), as well as their combination, under calcareous soil conditions, was investigated in this study.