Low expression of brown and beige fat genes in subcutaneous tissues in obese patients.

Introduction: The molecular mechanisms behind obesity pathogenesis remain largely undefined. Impairment in the browning process of subcutaneous tissues proposed to contribute to obesity pathogenesis. In the current study, we aimed to assess whether the expression of brown fat genes in subcutaneous tissues in obese patients is altered as compared to non-obese patients.

Gene Polymorphism Is Associated with Obesity and Blood Lipids Profiles in Saudi Population.

Aims: The PR domain containing 16 () gene and the Phosphodiesterase 4D () gene are both an essential regulators in the thermogenesis process in the brown adipose tissues (BAT). The influence of polymorphisms in those genes on obesity and blood lipids profile is unknown particularly in the Saudi population, so the current study is aiming to explore that.

Methods: A case control format was used that involved 89 obese individual and 84 non-obese (control).