Publications by authors named "Aisha Khaleeq"
Article Synopsis
- - The study addresses the issue of limited ancestral diversity in genome-wide association studies (GWAS), which makes it hard to find genetic risk variants in non-European ancestry groups, focusing on Alzheimer's Disease (AD).
- - Researchers analyzed a multi-ancestry GWAS dataset within the Alzheimer's Disease Genetics Consortium (ADGC) involving individuals from various ancestries, identifying 13 shared risk loci and 3 ancestry-specific loci, highlighting the benefits of diverse samples.
- - The findings underscore the importance of including underrepresented populations in genetic research, suggesting that even smaller sample sizes can lead to the discovery of novel genetic variants related to AD and implicating specific biological pathways like amyloid regulation and neuronal development.
Apolipoprotein E polymorphism and age at onset of Alzheimer's disease in a quadriethnic sample.
Dement Geriatr Cogn Disord
April 2011
Background: The relationship between the apolipoprotein E (ApoE) genotype and the risk for developing Alzheimer's disease (AD) or age at onset of AD is relatively well established in Caucasians, but less established in other ethnicities. We examined the association between the ApoE genotype and age at onset of AD in a quadriethnic group of community-dwelling AD patients.
Methods: AD patients were evaluated at 2 university-based outpatient memory disorder clinics.
Sentinel lymph node biopsy for sebaceous cell carcinoma and melanoma of the ocular adnexa.
Arch Otolaryngol Head Neck Surg
August 2007
Objective: To provide clinical details and long-term outcome data for a series of patients with eyelid or conjunctival melanoma or eyelid sebaceous cell carcinoma who underwent sentinel lymph node (SLN) biopsy.
Design: Retrospective interventional case series with review of clinical records and pathologic specimens.
Setting: Tertiary comprehensive cancer center.