Capsules with Ileocolonic-Targeted Release of Vitamin B, B, and C (ColoVit) Intended for Optimization of Gut Health: Development and Validation of the Production Process.

The ileocolonic-targeted delivery of vitamins can establish beneficial alterations in gut microbial composition. Here, we describe the development of capsules containing riboflavin, nicotinic acid, and ascorbic acid covered with a pH-sensitive coating (ColoVit) to establish site-specific release in the ileocolon. Ingredient properties (particle size distribution, morphology) relevant for formulation and product quality were determined.

Descriptive epidemiology of a cholera outbreak in Kaduna State, Northwest Nigeria, 2014.

Introduction: Cholera is an acute gastrointestinal infection caused by Vibrio cholerae, which may lead to severe dehydration and death if not treated. This analysis is aimed at highlighting the magnitude, pattern and trend of cholera outbreak that occurred in Kaduna State in 2014.

Methods: We obtained the 2014 cholera line-list from the Kaduna State Disease Surveillance and Notification officer (DSNO).