Publications by authors named "Aisaku Nakamura"

Objective: We prospectively monitored rates of change for growth, body mass and composition, muscle strength, and FEV1 in 6-11-year-olds initiating ETI therapy, comparing them to those of US reference children. We assessed factors potentially contributing to rate of change and report ranges of individual variation.

Methods: Body composition was assessed using bioelectrical impedance analysis (BIA), and rates of change were analyzed using linear mixed effects regression models.

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Background: Fatal overdoses involving fentanyl/fentanyl analogs (F/FA) have increased in the US, raising questions about naloxone doses for F/FA overdose reversal. Emergency medical services (EMS) data provide an opportunity to examine naloxone administration changes as fentanyl increases in the illicit opioid supply.

Methods: Administered naloxone intranasal-equivalent total dose (INTD) in milligrams (mg) was calculated for Kentucky EMS suspected opioid overdose (SOO) encounters (n=33,846), 2018-2021, and patterns of administration were examined.

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Article Synopsis
  • - The study investigates postoperative respiratory complications (PORCs) in children with laryngomalacia who underwent supraglottoplasty (SGP) for obstructive sleep apnea, highlighting limited data on risk factors associated with these complications.
  • - Out of 400 children analyzed, 23.1% experienced PORCs, with significant findings that children with congenital heart disease, higher obstructive apnea-hypopnea indexes (AHI), and lower oxygen saturation were more susceptible to these complications.
  • - The analysis concluded that a preoperative obstructive AHI > 10 events/h was the only significant independent risk factor for developing PORCs, emphasizing the importance of preoperative polysomnography in planning SGP surgeries.
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Objectives: Reports of interventions to improve dental opioid prescribing have come primarily from academic settings, but most opioid prescriptions are written by community dentists. This analysis compares prescription characteristics between these two groups to inform interventions to improve dental opioid prescribing in community settings.

Methods: State prescription drug monitoring program data from 2013 to 2020 were used to compare opioid prescriptions from dentists at academic institutions (PDAI) to prescriptions from dentists in non-academic settings (PDNS).

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Article Synopsis
  • Tooth extractions are a major reason for opioid prescriptions by dentists, and understanding factors influencing these prescriptions can help tailor interventions to minimize unnecessary use.* -
  • A study of over 44,000 patients revealed that 23.9% were prescribed opioids, with higher chances linked to factors like receiving nonopioid or antibiotic prescriptions, undergoing procedural sedation, and having multiple teeth extracted.* -
  • Certain conditions, such as appointments made in recent years, visits to student or resident clinics, and avoiding Fridays, were associated with lower opioid prescription rates, suggesting provider habits and clinical factors play a key role.*
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Objectives/hypothesis: To compare rates of post-tonsillectomy hemorrhage (PTH) between a very-low energy transfer monopolar technique (VLET) and standard energy techniques.

Study Design: Retrospective controlled cohort study.

Methods: All tonsillectomies performed by practice physicians during the period January 1, 2010 to August 31, 2019 were identified.

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