Decreased number of peripheral blood CD4 + CD29+ lymphocytes and increased in vitro spontaneous production of anti-DNA antibodies in patients with active systemic lupus erythematosus.

Flow cytometric 2-color analysis of peripheral blood lymphocytes from patients with systemic lupus erythematosus (SLE) showed a reduction of relative and absolute number of CD4+ CD29+ cells compared to matched healthy individuals. This abnormality was more marked in patients with active/very active disease. Absolute number of CD4+ CD29+ cells was negatively correlated with spontaneous anti-DNA Ig production that we demonstrated to be a laboratory index strongly correlated with a clinical disease activity score.

Lymphocytosis of large granular lymphocytes in splenectomized subjects.

Lymphocytosis of large granular lymphocytes (LGL) has been observed in 6 patients splenectomized for various pathological conditions. In all of them the LGL count was higher than 3.5 x 10(9)/l.

[Immunological follow-up of 95 HIV seropositive drug abusers in the bresciana area].

We evaluated 95 HIV seropositive drug-addicts during a follow-up period of one year. The patients were classified and reclassified at each visit, according to the criteria proposed by the Centers for Disease Control (CDC) in 1986. At the first visit the patients were classified as follows: 70 in IIa-IIIa, 23 in IIb-IIIb and 2 in group IV.

Kaposi's sarcoma in a young man in absence of AIDS or other known causes of immune suppression.

Kaposi's Sarcoma (KS) in young individuals is unusual and most often associated with cellular immunodeficiency caused by infective or other neoplastic diseases. It has recently been highly associated with the Acquired Immunodeficiency Syndrome (AIDS). We report the case of a heterosexual 29 year aged man with no evidence of underlying malignancy or infectious diseases.

Thermolabile alloalbumin of slow type: a new variant?

A new variant of Alloalbumin, with electrophoretic mobility identical to CISMEL standard SO/BS, characterized by thermolability at 56 degrees C of its slow migration band is described in this paper. This thermolabile Alloalbumin was present in 5 out of 10 family members of the original propositus. The new Alloalbumin has been indicated BS/BG according to the CISMEL recommendations.