Expression Pattern of the Reporter in Secretogranin III Gene-trapped Mice.

Secretogranin III (SgIII) is a granin protein involved in secretory granule formation in peptide-hormone-producing endocrine cells. In this study, we analyzed the expression of the in the knockout mice produced by gene trapping () for the purpose of comprehensively clarifying the expression patterns of SgIII at the cell and tissue levels. In the endocrine tissues of mice, expression was observed in the pituitary gland, adrenal medulla, and pancreatic islets, where SgIII expression has been canonically revealed.

Culture in 10% O enhances the production of active hormones in neuro-endocrine cells by up-regulating the expression of processing enzymes.

To closely mimic physiological conditions, low oxygen cultures have been employed in stem cell and cancer research. Although oxygen concentrations in tissues are often much lower than ambient 21% O (ranging from 3.6 to 12.