Febuxostat Attenuates the Induction of Vascular Cell Adhesion Protein 1 by TNF-α in Human Umbilical Vein Endothelial Cells.

In a randomized trial, higher all-cause and cardiovascular mortality was observed in treatment with febuxostat than with allopurinol in patients with coexisting gout and serious cardiovascular conditions. In this study, we focus on an intervention of febuxostat or allopurinol as an anti-inflammatory treatment to reduce the transcription of nuclear factor-kappa B (NF-κB) and production of relevant inflammatory factors. We evaluated the effect of febuxostat on vascular cell adhesion protein 1 (VCAM-1) induction in cultured human umbilical vein endothelial cells (HUVECs).

Influence of overnight orthokeratology on corneal endothelium.

Purpose: To evaluate the influence of overnight orthokeratology on the corneal endothelium.

Methods: Fifty-two eyes of 31 patients undergoing overnight orthokeratology for myopia were examined. They wore the lens every night and were followed up for at least 1 year.

Corneal iron ring formation associated with overnight orthokeratology.

Purpose: To describe a case of iron deposition in both eyes after overnight orthokeratology.

Methods: This is a case report of a 31-year-old man who underwent overnight orthokeratology. The subject was fitted with rigid gas-permeable contact lenses of reverse-geometry design to correct myopia.

Quantitative evaluation of regular and irregular corneal astigmatism in patients having overnight orthokeratology.

Purpose: To quantitatively assess changes in regular and irregular corneal astigmatism in patients having overnight orthokeratology.

Setting: Matsumoto Eye Clinic, Ibaraki, Japan.

Methods: A prospective study was conducted of 64 eyes of 39 patients having overnight orthokeratology for myopia.