Antibacterial and antioxidant studies of silver nanoparticles formulated from Erythrina senegalensis stem bark extract.

Erythrina senegalensis, belongs to the family of Fabaceae and it has been used traditionally to treat microbial infections and diabetes mellitus. The aim of this study was to formulate silver nanoparticles (AgNPs) from the methanol stem bark extract of Erythrina senegalensis and to evaluate the antibacterial and antioxidant effects of the nanoparticles. The methanol extract was screened qualitatively for the presence of tannins, alkaloids, saponins and flavonoids using standard protocols.

Formulation and in vitro evaluation of polymeric metronidazole nanoparticles.

The purpose of this research was to formulate metronidazole nanoparticles with the incorporation of acrylate methacrylate copolymer (Eudragit® RS 100) as the synthetic polymer using a nano spray-dryer. The formulated metronidazole nanoparticles were evaluated using scanning electron microscope, X-ray powder diffraction, differential scanning calorimetry and Fourier transform infra-red spectrophotometry. The results of the morphological analysis showed that the formulated nanoparticles were smooth, spherical with uniform distribution and polydispersity index (PDI) values between 0.

Development of Self-Emulsifying Drug Delivery Systems (SEDDSs) Displaying Enhanced Permeation of the Intestinal Mucus Following Sustained Release of Prototype Thiol-Based Mucolytic Agent Load.

In this study, mucoactive self-emulsifying drug delivery systems (SEDDSs) based on sustained release of N-acetylcysteine (NAC) were developed for providing effective intestinal mucopermeation. Polymeric ionic complexes of NAC were formed with polyethyleneimine (PEI), Eudragit E 100, and Eudragit RS 100 and loaded into a novel SEDDS. The SEDDSs exhibited a stable average size of 75 ± 12 nm (polydispersity index (PDI) < 0.

Development and in vitro analysis of floating matrix tablets of metronidazole using Brachystegia eurycoma gum.

Floating dosage forms aim to significantly increase the gastric residence time of drugs in the gastric region for several hours. Hence, this research was carried out to formulate and evaluate floating matrix tablets (FMT) of metronidazole using Brachystegia eurycoma (BE) gum as a matrix former. Floating matrix granules (FMG) were prepared by wet granulation method using the BE gum mucilage at different concentrations (2, 4, 6 and 8% w/w).