Impaired left ventricular diastolic function in athletes after utterly strenuous prolonged exercise.

Digitized M mode echocardiography was used to evaluate the effect of a competitive 24-h run on the left ventricular diastolic function in 12 well-trained marathon runners who completed 146-227 km during the race. Mitral valve opening was delayed, early diastolic filling was decreased and prolonged, and posterior wall thinning was reduced, particularly among those athletes completing close to 200 km or more. Since the alterations were in part the opposite in those running 160 km or less, only the reductions in the peak rate of dimension increase (P less than 0.

Echocardiographic evaluation of left ventricular response to isometric exercise in young insulin-dependent diabetics.

In order to evaluate the left ventricular (LV) response to isometric exercise in diabetics, 15 young insulin-dependent diabetic subjects and 12 control subjects of similar age and sex distribution performed a handgrip test during echocardiography. No base-line differences in hemodynamic or echocardiographic parameters were found between diabetic and control subjects. The heart rate and blood pressure responses to handgrip exercise were similar in the two groups, and LV dimensions, shortening fraction and velocity of circumferential fiber shortening remained unchanged in both groups.

Intravenous insulin has no effect on myocardial contractility or heart rate in healthy subjects.

To evaluate the acute effects of intravenous insulin on myocardial contractility and heart rate, echocardiography was performed in 12 healthy subjects and continuous heart rate recording in 11 healthy subjects before and during euglycaemic insulin and glucose infusion. The rate of insulin infusion was 0.5-1.

Cardiovascular response to exercise in young women with insulin-dependent diabetes mellitus.

To evaluate the cardiovascular response to exercise in diabetes, a graded maximal exercise test was performed on 50 women with insulin-dependent diabetes mellitus, aged 15-40 years, and on 15 healthy women in the same age group. The diabetic subjects were divided into 3 groups according to the duration of disease: group 1: 0-5 years, group 2: 6-14 years, group 3: 15-29 years. The maximal work load was lower in the diabetic subjects than in the controls.

Impaired left ventricular filling in young female diabetics. An echocardiographic study.

To assess left ventricular (LV) function in diabetes mellitus, M-mode echocardiograms were recorded in 36 insulin-treated diabetic women, mean age 25 +/- 6 (SD) years, and 13 healthy women of the same age. Echocardiographic tracings of the septum and LV posterior wall were digitized and continuous plots were made of LV dimension and its rate of change. The pattern of LV filling was abnormal in 19 diabetics, when the mean value +/- 2 SD in the healthy women was taken as the normal range of the indices.

Systolic time intervals and the QT-QS2 interval in young female diabetics.

To detect subclinical cardiomyopathy in diabetic patients without evidence of coronary artery disease, systolic time intervals were measured in 51 insulin-treated young female diabetics (mean age 27 years and mean duration of diabetes 12 years) and in 15 healthy women of the same age. The ratio of the pre-ejection period to the left ventricular ejection time (PEP/LVET) was used as an index of left ventricular performance. The PEP/LVET ratio was normal in all diabetics and did not differ statistically from that in the control group.