N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) mitigates the liver fibrosis via WTAP/mA/Ptch1 axis through Hedgehog pathway.

N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous tetrapeptide with potential antifibrotic effect. However, the underlying mechanism in the anti-fibrosis is still unclear. Here, we try to investigate its biofunction and deeplying mechanism in liver fibrosis.

Anxiety and depression in glioma patients: prevalence, risk factors, and their correlation with survival.

Aims: This study aimed to investigate the risk factors and prognostic value of anxiety and depression in glioma patients.

Methods: A total of 190 glioma patients who underwent resection were consecutively enrolled. Anxiety was assessed using hospital anxiety and depression scale (HADS) and Zung self-rating anxiety scale (SAS); depression was assessed with the use of HADS and Zung self-rating depression scale (SDS).

[Bioinformatic analysis of pygo1 gene in Homo sapiens].

Objective: To analyze the structure and function of PYGO1 protein with bioinformatics.

Methods: The bioinformatic methods and tools were used to analyze the physical and chemical properties, transmembrane region, hydrophobicity and hyrdrophilicity, secondary structure and functional category of PYGO1 protein.

Results: The bioinformatic analysis revealed that proline content was the highest of all amino acid residues in PYGO1 protein; the molecular formula was C(1943)H(2937)N(577)O(635)S(18) with a relative molecular mass of 45; and the theoretical isoelectric point was 6.

Investigation of single nucleotide polymorphisms based on the intronic sequences of the propylene alcohol dehydrogenase gene in Chinese tobacco genotypes.

A pair of primers was designed to amplify the propylene alcohol dehydrogenase gene sequence based on the cDNA sequence of the tobacco allyl-alcohol dehydrogenase gene. All introns were sequenced using traditional polymerase chain reaction (PCR) methods and T-A cloning. The sequences from common tobacco ( L.

[Chloroplast genetic engineering: a new approach in plant biotechnology].

Chloroplast genetic engineering, offers several advantages over nuclear transformation, including high level of gene expression, increased biosafety, remedying some limitations associated with nuclear genetic transformation, such as gene silencing and the stability of transformed genes. It is now regarded as an attractive new transgenic technique and further development of biotechnology in agriculture. In this article we reviewed the characteristics, applications of chloroplast genetic engineering and its promising prospects were discussed.