Aс/Bi generator for direct synthesis of Bi-labeled bioconjugates.

Background: Bi is a short-lived radionuclide currently trialed for alpha therapy of various oncological diseases. A serious obstacle to the wide medical use is decay losses of Bi during a conventional synthesis of radiopharmaceuticals. In this work, we aimed to develop a two-column Aс/Bi generator providing the accumulation of Bi separately from the parent Ac via continuous circular separation and decay of intermediate Fr.

Rapid Elution of Th from a Two-Column U/Th Generator with Diluted and Buffer Solutions.

A radionuclide generator of the short-lived alpha emitter Th was proposed. An original scheme consisting of two in-series chromatographic columns was developed for rapidly producing a neutral citric-buffered eluate of high purity Th. The first column filled with TEVA resin retained the parent U, while Th was eluted with 7 M HCl solution to be immediately adsorbed on the second column containing DGA resin or UTEVA resin.