Publications by authors named "Ainhize Urkola-Arsuaga"
λ-type carrageenan (λ-CAR) polysaccharides remain overlooked in the preparation of medical nanoparticles (NP) due to their unsuitable rheological properties and undesired biological effects, although they can also offer advantageous properties. To overcome these obstacles, oligosaccharide derivatives (λ-COS) have been successfully applied to the synthesis of stable NP incorporating both, ferrite cores and divalent manganese (Mn) releasable ions. The acute pro-inflammatory behavior and anticoagulant activity of native λ-CAR were significantly reduced in the case of λ-COS and λ-COS NP, rendering possible their use for medical applications.
View Article and Find Full Text PDFBackground: Pulmonary arterial hypertension (PAH) is a severe disease characterized by elevated blood pressure in the pulmonary artery that can ultimately damage the right ventricle of the heart. PAH is pathophysiologically heterogeneous, which makes early diagnosis and treatment difficult. Inflammation is thought to be an important factor in the development and progression of this disease and may explain some of the observed interindividual differences.
View Article and Find Full Text PDFArticle Synopsis
- - Atherosclerosis is a serious disease that can lead to heart attacks and strokes, but diagnosing vulnerable plaques is difficult because current methods lack accuracy and specificity.
- - New technologies are being developed using customized nanoparticles for noninvasive imaging of atherosclerotic plaques, which can improve diagnosis and prediction of plaque rupture risk.
- - Our research focuses on comparing the imaging effectiveness of different nanoparticles, demonstrating that Gd (III)-doped amorphous calcium carbonate nanoparticles are promising for targeted imaging of atherosclerosis, particularly when functionalized with specific ligands for targeting calcifications and inflammation.