DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads.

Study Question: Does loss of DMRT1 in human fetal testis alter testicular development and result in testicular dysgenesis?

Summary Answer: DMRT1 repression in human fetal testis alters the expression of key testicular and ovarian determining genes, and leads to focal testicular dysgenesis.

What Is Known Already: Testicular dysgenesis syndrome (TDS) is associated with common testicular disorders in young men, but its etiology is unknown. DMRT1 has been shown to play a role in the regulation of sex differentiation in the vertebrate gonad.

'Abortion' or 'termination of pregnancy'? Views from abortion care providers in Scotland, UK.

Background: The phrase 'termination of pregnancy' has recently been adopted by a number of British medical institutions as a preferred descriptor of induced abortion. How it is used by abortion care providers is unclear, although the ongoing stigmatisation of abortion may play a role.

Methods: A mixed methods study of the views of abortion care providers in Scotland, UK.