Publications by authors named "Aina Tilups"
OCTN3 is a mammalian peroxisomal membrane carnitine transporter.
Biochem Biophys Res Commun
December 2005
Article Synopsis
- Carnitine is crucial for fatty acid metabolism, helping to regulate important CoA pools in cells and acting as a shuttle between different cellular compartments.
- Researchers have identified the presence of the mOctn3 carnitine transporter in murine liver peroxisomes and its expression in human fibroblasts, indicating its role in carnitine transport within the cell.
- The study shows reduced levels of hOCTN3 in certain peroxisomal biogenesis disorders, reinforcing its localization on peroxisomal membranes and highlighting its importance in lipid metabolism.
Campylobacter jejuni and Mycobacterium paratuberculosis have been implicated in the pathogenesis of Crohn's disease. The presence of bacterial metabolites in the colonic lumen causing a specific breakdown of fatty acid oxidation in colonic epithelial cells has been suggested as an initiating event in inflammatory bowel disease (IBD). l-Carnitine is a small highly polar zwitterion that plays an essential role in fatty acid oxidation and ATP generation in intestinal bioenergetic metabolism.
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