Platelet-activating factor contracts guinea pig esophageal muscularis mucosae by stimulating extracellular Ca influx through diltiazem-insensitive Ca channels.

Platelet-activating factor (PAF) is expected to increase esophageal motility. However, to the best of our knowledge, this has not been examined. Thus, we investigated the contractile effects of PAF on guinea pig (GP) esophageal muscularis mucosae (EMM) and the extracellular Ca influx pathways responsible.