Publications by authors named "Aina D R Ramirez"
Background: The innate immune response plays an important role during malaria. Toll-like receptors (TLR) are capable of recognizing pathogen molecules. We aimed to evaluate five polymorphisms in TLR-4, TLR-6, and TLR-9 genes and their association with cytokine levels and clinical parameters in malaria from the Brazil-French Guiana border.
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- The study investigates the role of TREM-1 gene polymorphisms in the immune response to malaria, specifically in patients infected with Plasmodium vivax in the Brazilian Amazon.
- Researchers analyzed blood samples from 76 infected individuals and 144 healthy controls, measuring various cytokines and antibodies to understand their relationship with TREM-1 polymorphisms.
- Results showed significant associations between certain gene variants and increased levels of inflammatory cytokines in malaria patients, suggesting these SNPs could influence the severity of the disease.