Publications by authors named "Ain' Sabreena Mohd Noh"
Article Synopsis
- The role of carbon monoxide (CO) in the body is complex, functioning both as a gasotransmitter that influences neurotransmitter regulation and as a possible therapeutic agent with protective effects against various health issues.
- Research has explored the potential benefits of low-concentration CO inhalation, but its use is limited due to the risk of toxicity from carboxyhaemoglobin formation.
- Carbon monoxide releasing molecule-2 (CORM-2) has been developed to provide a controlled release of CO, which may alleviate pain, particularly in chronic and neuropathic conditions, as discussed in this review.
Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disease that causes prolonged inflammation, joint damage, and persistent pain, indicating that factors beyond inflammation may contribute to suffering.
- Numerous studies reveal a connection between imbalanced apoptotic regulations, increased inflammatory cells, and heightened pain sensitivity in RA.
- Understanding how abnormal apoptosis influences pain in RA could lead to new therapeutic strategies aimed at reducing pain and improving patient outcomes.
Complete Freund's adjuvant (CFA) has been used to develop the arthritic or inflammatory condition in the animal, but there is a lack of information concerning high CFA doses on nociceptive behaviour and inflammatory parameters. This study aimed to compare the effects of different high doses of CFA in rat to closely mimic nociceptive and inflammatory parameters of rheumatoid arthritis (RA) in humans. Twenty-four male Sprague-Dawley rats were randomly divided into four groups (n = 6): Control (C), CFA-induced polyarthritic groups at 5.
View Article and Find Full Text PDFPain is the most common symptom reported by patients with rheumatoid arthritis (RA) even after the resolution of chronic joint inflammation. It is believed that RA-associated pain is not solely due to inflammation, but could also be attributed to aberrant modifications to the central nervous system. The P2X4 receptor (P2X4R) is an ATP-activated purinergic receptor that plays a significant role in the transmission of information in the nervous system and pain.
View Article and Find Full Text PDFChronic pain is a debilitating condition that occurs after tissue damage, which substantially affects the patient's emotional state and physical activity. The chronic pain in rheumatoid arthritis (RA) is the result of various autoimmune-induced inflammatory reactions in the joints. Both types of peripheral and central pain processing can lead to sensitisation.
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