Publications by authors named "Aimin Sun"

Background: The Fontan procedure is a surgical intervention designed for patients with single ventricle physiology, wherein the systemic venous return is redirected into the pulmonary circulation, thereby facilitating passive pulmonary blood flow without the assistance of ventricular propulsion. Consequently, long-term follow-up of individuals who have undergone the asymptomatic Fontan procedure is essential.

Objectives: The aims of this investigation were to: 1) examine the impact of flow components and kinetic energy (KE) parameters on hemodynamic disturbances in asymptomatic Fontan patients and control group; 2) Assess left ventricular diastolic dysfunction through the analysis of 4D flow parameters across different Fontan sub-groups; 3) Compare intracardiac flow parameters among Fontan sub-groups based on morphological features of the left ventricle (LV) and right ventricle (RV).

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  • The study looked at biventricular function in patients who had an arterial switch operation (ASO) to better understand how their heart dynamics differ from healthy individuals.
  • It involved 34 ASO patients and 17 matched controls, using advanced imaging techniques to analyze various blood flow parameters and kinetic energy in both the left and right ventricles.
  • Results showed that ASO patients had significantly reduced measures of vorticity in their left ventricle compared to controls, indicating potential functional declines in heart function.
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  • * An analysis of 12 studies involving 219 patients showed significant improvements in symptoms like swelling and double vision, with a low rate of severe side effects.
  • * The findings suggest TCZ is a promising alternative for patients not responding to traditional glucocorticoid treatments, but further large-scale studies are needed for confirmation.
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Extranodal Natural Killer/T Cell Lymphoma Nasal Type (EN-NK/T-CL-NT) is a rare type of non-Hodgkin lymphoma in which the lesion is usually located in the upper respiratory tract, such as nasal cavity, palate, and nasopharynx. In addition, the primary lesion of EN-NK/T-CL-NT can rarely originate in extranasal sites such as the skin, gastrointestinal tract, testicles, central nervous system, and lungs. We describe an 82-year-old male smoker was brought to the hospital with 8 months of fever, cough, sputum production, chest pain, and chest tightness.

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Background: Lung cancer is the most common cause of cancer death worldwide and poses an immediate health threat. Despite decades of basic and clinical research, the 5-year survival rate for lung cancer patients is less than 10%.The most important drawbacks in efficient treatment of lung cancer are delayed diagnosis and absence of effective screening.

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  • The study focuses on creating a prognostic model to predict HBsAg loss in patients with chronic hepatitis B (CHB) undergoing antiviral treatment, which currently rarely occurs with existing therapies.
  • Data from 6,792 patients treated with nucleos(t)ide analogues were analyzed, leading to the development of the GOLDEN model that integrates longitudinal HBsAg measurements.
  • The GOLDEN model demonstrated high accuracy in predicting HBsAg clearance, effectively identifying patients likely to achieve this outcome, which could improve patient stratification in future treatments.
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Objectives: To develop and validate a predictive method for axillary lymph node (ALN) metastasis of breast cancer by using radiomics based on mammography and MRI.

Materials And Methods: A retrospective analysis of 492 women from center 1 (The affiliated Hospital of Qingdao University) and center 2 (Yantai Yuhuangding Hospital) with primary breast cancer from August 2013 to May 2021 was carried out. The radscore was calculated using the features screened based on preoperative mammography and MRI from the training cohort of Center 1 (n = 231), then tested in the validation cohort (n = 99), an internal test cohort (n = 90) from Center 1, and an external test cohort (n = 72) from Center 2.

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Objectives: Cardiovascular magnetic resonance (CMR) imaging is routinely performed for assessing right ventricular (RV) systolic but not diastolic function. We aimed to investigate CMR-based assessment of RV diastolic function in pediatric patients with repaired tetralogy of Fallot (rTOF), compared to transthoracic echocardiography (TTE) measurements.

Methods: A total of 130 consecutive pediatric patients with rTOF who underwent clinically indicated CMR and same-day TTE were included.

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Background & Aims: Current hepatocellular carcinoma (HCC) risk scores do not reflect changes in HCC risk resulting from liver disease progression/regression over time. We aimed to develop and validate two novel prediction models using multivariate longitudinal data, with or without cell-free DNA (cfDNA) signatures.

Methods: A total of 13,728 patients from two nationwide multicenter prospective observational cohorts, the majority of whom had chronic hepatitis B, were enrolled.

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We conducted a meta-analysis to assess the effect of endoscopic submucosal dissection compared with gastrectomy on the wound infection in early stomach cancer subjects. A systematic literature search up to November 2022 was performed and 2765 related studies were evaluated. The chosen studies comprised 7842 early stomach cancer subjects participated in the selected studies' baseline trials; 3308 of them used the endoscopic submucosal dissection, while 4534 used gastrectomy.

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(1) Background: The left atrium (LA) is much more than a reservoir for left ventricular filling. The aim of this study was to assess the LA volume and function in patients with repaired pulmonary artery atresia with ventricular septal defect (rPA/VSD) using CMR. (2) Methods: 31 pediatric patients with rPA/VSD and 30 healthy controls were prospectively recruited.

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Cancer patients are at high risk of infections and infection-related mortality; thereby, prompt diagnosis and precise anti-infectives treatment are critical. This study aimed to evaluate the performance of nanopore amplicon sequencing in identifying microbial agents among immunocompromised cancer patients with suspected infections. This prospective study enlisted 56 immunocompromised cancer patients with suspected infections.

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Objective: This study is aimed at exploring the efficacy of transarterial chemotherapy embolization (TACE)+radiofrequency ablation+sorafenib in the treatment of patients with recurrent liver cancer and at constructing its prediction model.

Methods: A total of 60 patients with recurrent liver cancer treated in our hospital from March 2020 to March 2022 were enrolled and divided into two groups according to treatment methods, with 30 patients in each group. Group A adopted TACE+radiofrequency ablation+sorafenib therapy while group B adopted TACE+radiofrequency ablation therapy.

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Purpose: This study aimed at exploring the feasibility and reproducibility of CCT for the measurement of Left Atrial (LA) strain and volume compared with transthoracic echocardiography (TTE) in pediatric patients with congenital heart disease (CHD).

Materials And Methods: The present study included 43 postoperative patients with CHD (7.39 ± 3.

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Background: To assess the accuracy and reproducibility of right ventricular (RV) and left ventricular (LV) function and flow measurements in children with repaired tetralogy of Fallot (rTOF) using four-dimensional (4D) flow, compared with conventional two-dimensional (2D) magnetic resonance imaging (MRI) sequences.

Methods: Thirty pediatric patients with rTOF were retrospectively enrolled to undergo 2D balanced steady-state free precession cine (2D b-SSFP cine), 2D phase contrast (PC), and 4D flow cardiac MRI. LV and RV volumes and flow in the ascending aorta (AAO) and main pulmonary artery (MPA) were quantified.

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Objective: We explored the feasibility of cardiac computed tomography (CCT) to evaluate postoperative ventricular function in children with congenital heart disease (CHD) and evaluated the accuracy and reproducibility of CCT using cardiac magnetic resonance (CMR) as a reference.

Methods: Thirty-two postoperative children with CHD (20 boys and 12 girls) who underwent CMR and CCT were enrolled. Left and right ventricular ejection fraction, end-diastolic volume, end-systolic volume, stroke volume, and cardiac index were measured using cardiac function analysis software.

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Objective: To investigate the feasibility of cine three-dimensional (3D) balanced steady-state free precession (b-SSFP) imaging combined with a non-local means (NLM) algorithm for image denoising in evaluating cardiac function in children with repaired tetralogy of Fallot (rTOF).

Materials And Methods: Thirty-five patients with rTOF (mean age, 12 years; range, 7-18 years) were enrolled to undergo cardiac cine image acquisition, including two-dimensional (2D) b-SSFP, 3D b-SSFP, and 3D b-SSFP combined with NLM. End-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF) of the two ventricles were measured and indexed by body surface index.

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Article Synopsis
  • This study examined the use of cardiac computed tomography (CCT) to evaluate global strain in the left ventricle of post-surgery children with congenital heart disease (CHD) and compared it to standard transthoracic echocardiography (TTE).
  • A total of 51 patients were analyzed, revealing that CCT and TTE provided similar results for global longitudinal strain (GLS) and global circumferential strain (GCS), but there was a significant difference in global radial strain (GRS).
  • Overall, CCT showed good consistency and reproducibility for measuring left ventricular strain, making it a valuable tool for certain pediatric patients with CHD, especially when TTE is
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The stability of IFN-γ as a therapeutic protein can play a key role on its anticancer effects. Herein, we explored the thermodynamic parameters and conformational stability of IFN-γ in the presence of calycosin, the main active compound of Radix astragali, by different biophysical and theoretical analysis. Afterwards, the improved anticancer effects of IFN-γ-calycosin interaction relative to IFN-γ alone were assessed on hepatocellular carcinoma (HepG2) cell line by MTT and caspase assays.

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The aim of this study is to explore the feasibility of using a non-sedation protocol for the evaluation of neonatal congenital heart disease by using 16-cm wide-detector CT with a low radiation dose. Thirty-four neonates (group 1) were enrolled to undergo cardiac CT without sedation between August 2018 and March 2019. The control group (group 2) comprising 20 inpatient neonates was sedated.

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Article Synopsis
  • - This study evaluated the heart function of asymptomatic children who have undergone repair for tetralogy of Fallot (rTOF) using advanced cardiovascular magnetic resonance (CMR) techniques, specifically looking for abnormalities in the right ventricle (RV) despite normal ejection fraction (EF).
  • - Researchers compared 100 rTOF patients with 52 control subjects and found that key indicators of heart function (like TAPSE and RV global longitudinal strain) were significantly lower in the rTOF group, indicating hidden dysfunction.
  • - The results highlighted that a large number of rTOF patients exhibited signs of RV dysfunction, especially females, suggesting that preserved EF might not reflect the true health of the heart in these youngsters.
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Background: This study aimed to assess the severity of helix and vortex flow in pulmonary artery hemodynamic using 4-dimensional flow cardiac magnetic resonance (4D flow CMR) in patients with repaired tetralogy of Fallot (rTOF) and healthy child volunteers and to explore the relationship between pulmonary hemodynamic changes and right heart function.

Methods: CMR studies were performed in 25 rTOF patients (15 M/10 F; 8.44±4.

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Background: This study aimed to investigate the associations between cardiac strain, cardiac torsion, ventricular volumes, and ventricular ejection fraction, with N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in Fontan patients who were age- and gender-matched with healthy control subjects.

Methods: Cardiovascular magnetic resonance (CMR) studies performed in 22 (15 male, 7 female) patients with single-ventricle physiology (all morphological left ventricles) palliated with Fontan and 17 (10 male, 7 female) age- and gender-matched healthy children volunteers were retrospectively analyzed. Serum NT-proBNP levels were obtained in Fontan subjects.

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Background: The accuracy of 2D and 3D strain analyses was evaluated by comparing strain and cardiac function parameters in Fontan repair patients and normal child volunteers.

Methods: We retrospectively enrolled 32 patients with Fontan circulation and 32 child volunteers who had undergone clinical cardiac magnetic resonance (CMR) assessment of the dominant ventricle with a 1.5-Tesla MRI scanner.

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The epigenetic silencing mechanism of suppressor 3 of cytokine signaling (SOCS3) in cancers has not been fully elucidated. Polycomb repressive complexes 2 (PRC2), an important epigenetic regulatory factors, exerts a critical role in repressing the initial phase of gene transcription. Whether PRC2 participates the down- regulation of SOCS3 in Hepatocellular carcinoma (HCC) remains unclear and how does PRC2 be recruited target gene still needs to explore.

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Synopsis of recent research by authors named "Aimin Sun"

  • - AiMin Sun's research focuses on novel methodologies in cardiovascular imaging and predictive modeling for various health conditions, with a strong emphasis on understanding complex hemodynamics in congenital heart defects and evaluating treatment efficacy for autoimmune disorders.
  • - Recent studies include a comprehensive examination of biventricular hemodynamics in patients post-arterial switch operation, and the effectiveness of intravenous tocilizumab for Graves' ophthalmopathy, highlighting the significance of advanced imaging techniques and systematic reviews in clinical outcomes.
  • - Additionally, AiMin Sun is investigating risk prediction models for hepatocellular carcinoma and breast cancer metastasis, utilizing longitudinal patient data and advanced diagnostic methodologies, such as radiomics, to enhance diagnostic accuracy and treatment strategies.

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