Allele Frequency in Southern Greece: Exploring the Role of Geographical Gradient in the Greek Population.

Background: the apolipoprotein e4 allele () constitutes an established genetic risk factor for Alzheimer's Disease Dementia (ADD). We aimed to explore the frequency of the isoforms in the Greek population of Southern Greece.

Methods: peripheral blood from 175 Greek AD patients, 113 with mild cognitive impairment (MCI), and 75 healthy individuals.