Publications by authors named "Aimi Watanabe"
Signal transducer and activator of transcription (STAT) 3 is a key factor in homeostasis of the oral mucosa by regulating the production of inflammatory cytokines. Sunitinib is a substrate of P-glycoprotein (multidrug resistance (MDR)-1/ABCB1) and breast-cancer resistance protein (BCRP/ABCG2). In this retrospective study, we evaluated the association between sunitinib-induced stomatitis and STAT3, ABCB1, and ABCG2 polymorphisms in patients with metastatic renal cell carcinoma (mRCC).
View Article and Find Full Text PDFArticle Synopsis
- STAT3 is essential for how renal cell carcinoma (RCC) responds to multiple tyrosine kinase inhibitors (mTKIs), as this study explores the link between certain genetic variations (SNPs) in the STAT3 gene and treatment outcomes.
- The research involved 71 patients with clear cell RCC, finding that a specific SNP (rs4796793) showed a significant association with better tumor responses to mTKIs, with higher response rates in those with the C/C genotype compared to other genotypes.
- While the results indicated that the rs4796793 genotype could be a new predictive marker for mTKI response in metastatic RCC, further studies with larger groups are needed to validate these findings.
Innovations in data visualization punctuate the landmark advances in human connectome research since its beginnings. From tensor glyphs for diffusion-weighted imaging, to advanced rendering of anatomical tracts, to more recent graph-based representations of functional connectivity data, many of the ways we have come to understand the human connectome are through the intuitive insight these visualizations enable. Nonetheless, several unresolved problems persist.
View Article and Find Full Text PDF