Publications by authors named "Aimi Kawano"
Article Synopsis
- Borderline personality disorder (BPD) is marked by emotional instability, tumultuous relationships, and issues with self-identity.
- The study involved measuring stress hormone levels in BPD patients and comparing their psychological responses to those of a control group during stress tests.
- Results showed that BPD patients exhibited significantly higher anxiety and depression levels and varying hormonal responses to stressors based on gender, indicating different stress response mechanisms among males and females.
Background: Decreased expression of brain-derived neurotrophic factor (BDNF) is implicated in enhanced stress responses. The BDNF Val66Met polymorphism is associated with psychological changes; for example, carriers of the Met allele exhibit increased harm avoidance as well as a higher prevalence of depression and anxiety disorder.
Methods: To analyze the effects of BDNF Val66Met on stress responses, we tested 226 university students (88 women and 138 men) using a social stress procedure (Trier Social Stress Test [TSST]) and an electrical stimulation stress test.
Association of microcephalin 1, syntrophin-beta 1, and other genes with automatic thoughts in the Japanese population.
Am J Med Genet B Neuropsychiatr Genet
September 2014
Automatic thoughts may be risk factors for depression and anxiety, and should be detected early. However, the genetic basis of automatic thoughts remains unclear. This study aims to investigate the genetic association of automatic thoughts with SNPs (single nucleotide polymorphisms) involved in cognition, neurogenesis, neuronal cell structure, neurotransmitters, hypothalamus-pituitary adrenal axis and psychiatric illness.
View Article and Find Full Text PDFBackground: Bipolar disorder (BP) is often associated with a change in hypothalamus- pituitary-adrenal axis function change due to chronic stress. Salivary α-amylase (sAA) levels increase in response to psychosocial stress and thus function as a marker of sympathoadrenal medullary system activity. However, sAA has been studied less often than salivary cortisol in BP patients.
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- Salivary α-amylase (sAA) is a potential indicator of stress response linked to the sympathoadrenal medullary system; this study examines its levels in patients with obsessive-compulsive disorder (OCD) compared to healthy individuals.
- Findings show that OCD patients exhibited significantly higher scores for anxiety and depression while having lower vigor compared to healthy controls, but no differences were observed in heart rate variability (HRV) between the two groups.
- The research indicates that OCD patients had elevated sAA levels under stress, suggesting a heightened sensitivity to stressors, potentially marking a unique characteristic of OCD.
Article Synopsis
- Salivary alpha-amylase (sAA) and cortisol were measured in healthy volunteers after stress tests to assess their roles in stress response, revealing distinct patterns in each biomarker.
- Participants were tested with the Trier Social Stress Test (TSST) and electric stimulation stress, showing that sAA spiked quickly and returned to normal, while cortisol rose more slowly and stayed elevated longer.
- Findings indicated no gender differences in sAA responses, but females had higher cortisol levels after the TSST, and younger participants exhibited greater sAA activity, linking cortisol levels to stress intensity.
Psychosocial stress-induced activation of salivary α-amylase (sAA) functions is as a marker of sympathoadrenal medullary system (SAM) activity. However, in contrast to salivary cortisol, sAA has been less extensively studied in panic disorder patients. The present study measured sAA and salivary cortisol levels in patients with panic disorder following electrical stimulation stress.
View Article and Find Full Text PDFSalivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in major depressive disorder patients.
Prog Neuropsychopharmacol Biol Psychiatry
March 2012
Major depressive disorder (MDD) is often associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis by chronic stress. In comparison, psychosocial stress-induced activation of salivary α-amylase (sAA) functions as a marker of sympathoadrenal medullary system (SAM) activity. However, in contrast to salivary cortisol, sAA has been less extensively studied in MDD patients.
View Article and Find Full Text PDFElevated salivary α-amylase and cortisol levels in unremitted and remitted depressed patients.
Int J Psychiatry Clin Pract
November 2010
Abstract Objective. Major depressive disorder (MDD) is often associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis via chronic stress. Psychosocial stress-induced activation of salivary α-amylase (sAA) represents sympathoadrenal medullary system (SAM) activity, and sAA has become an emerging biomarker for sympathetic nervous system activity.
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