Association of rs7216389 Polymorphism in Gasdermin B (GSDMB) With Childhood Asthma: A Case-Control Study.

Objective This study examines the association between the gasdermin B (GSDMB) gene variant rs7216389 and childhood asthma, with a focus on gender-based differences, environmental factors, and lung function measurements in affected children. It highlights the growing prevalence of childhood asthma, its unique features compared to adult-onset asthma, and the substantial healthcare burden it imposes, especially during exacerbations. Methods A case-control study was conducted over 18 months at CMH Lahore, UHS, and Children's Hospital, including 200 participants (100 asthmatics, 100 controls) aged three to 18.