Risk assessment of and variants in B-acute lymphoblastic leukemia: a case-control study in a Pakistani cohort.

Aims: B-cell acute lymphoblastic leukemia (B-ALL) is amongst the most prevalent cancers of children in Pakistan. Genetic variations in are associated with auto-phosphorylation of kinase domain that leads to increased proliferation of blast cells. Paired box family of transcription factor () plays a critical role in commitment and differentiation of B-cells.