Construction of Low-Crystallinity Three-Dimensional Flower-like Cobalt-Doped Nickel Hydroxide for High-Performance Nickel-Zinc Batteries.

The main limitations of aqueous nickel-zinc batteries are their relatively low energy density and short cycle life, which are inextricably linked to the limitations of nickel-based cathodes. In this study, a low-crystallinity flower-like cobalt-doped nickel hydroxide (α-Ni(OH)-0.2Co) is constructed by hydrothermal reaction and employed as high-energy-density cathode for aqueous rechargeable nickel-zinc batteries.

Camrelizumab Combined with Apatinib for Portal Vein Tumor Thrombus in Advanced Hepatocellular Carcinoma: Two Case Reports.

Portal vein tumor thrombus (PVTT) is a common complication of primary hepatocellular carcinoma (HCC). HCC typically infiltrates intrahepatic vessels, particularly the portal vein, leading to the formation of PVTT, marking advanced-stage HCC and correlating with poor prognosis. PVTT often complicates local treatment strategies such as surgical resection and affects the efficacy of interventions.

Duodenal-Jejunal bypass improves metabolism and re-models extra cellular matrix through modulating ceRNA network.

Background: Bariatric surgery (BS) is an effective approach in treating obesity and ameliorating T2DM with obesity. Our previous studies demonstrated that duodenal-jejunal bypass (DJB) altered long non-coding RNAs (lncRNAs) in the gastrointestinal system, which is associated with modulation of lipid metabolism, and glycemic control through entero-pancreatic axis and gut-brain axis. The adipose non-coding RNA expression profile and the underlying competing endogenous RNA (ceRNA) regulatory network pattern post DJB needs further research and investigation.

Pharmacology-Based Prediction of the Targets and Mechanisms for Icariin against Myocardial Infarction.

This study aims to illustrate the mechanisms underlying the therapeutic effect of Icariin after myocardial infarction (MI). Based on the network pharmacology strategy, we predict the therapeutic targets of Icariin against MI and investigate the pharmacological molecular mechanisms. A topological network was created.

Towards High-Performance Supercapacitor Electrodes via Achieving 3D Cross-Network and Favorable Surface Chemistry.

Transition metal phosphides/phosphates (TMPs) are considered appealing electrode materials in energy-related fields, especially in supercapacitors. However, the dilemma of inadequate electrode kinetics and dimensional unreliability evoked by a huge volume variation during cycling significantly plagues their progress. To mitigate this issue, in this work, a 3D cross-network in situ assembled via self-derived N-doped carbon hybrid Ni-Co-P/POx 2D sheets is fabricated.

Graphene Quantum Dots Pinned on Nanosheets-Assembled NiCo-LDH Hollow Micro-Tunnels: Toward High-Performance Pouch-Type Supercapacitor via the Regulated Electron Localization.

A combined delicate micro-/nano-architecture and corresponding surface modification at the nanometer level can co-tailor the physicochemical properties to realize an advanced supercapacitor electrode material. Herein, nanosheets-assembled nickel-cobalt-layered double hydroxide (NiCo-LDH) hollow micro-tunnels strongly coupled with higher-Fermi-level graphene quantum dots (GQDs) are reported. The unique hollow structure endows the electrolyte accessible to more electroactive sites, while 2D nanosheets have excellent surface chemistry, which favors rapid ion/electron transfer, synergistically resulting in more super-capacitive activities.

circ_ARF3 regulates the pathogenesis of osteosarcoma by sponging miR-1299 to maintain CDK6 expression.

Increasing evidence suggests that circular RNAs are emerging biomarkers or targets for early cancer diagnosis and treatment. However, the studies of circular RNA in osteosarcoma (OS) are limited. In this study we found that circ_ARF3 were highly expressed in osteosarcoma cell lines and tumor tissues.

Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis.

Chemo-resistance is a serious obstacle for successful treatment of cancer. Apigenin, a dietary flavonoid, has been reported as an anticancer drug in various malignant cancers. This study aimed to investigate the potential chemo-sensitization effect of apigenin in doxorubicin-resistant hepatocellular carcinoma cell line BEL-7402/ADM.

Apigenin sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway.

Chemo-resistance is one of the main obstacle in hepatocellular carcinoma therapy. Apigenin as a natural bioflavonoid has been exhibited anti-cancer properties in various malignant cancers. The aim of this study is to evaluate the potential chemo-sensitization effect of apigenin in doxorubicin-resistant hepatocellular carcinoma cell line BEL-7402/ADM and to investigate its possible mechanism.

Supramolecule-Inspired Fabrication of Carbon Nanoparticles In Situ Anchored Graphene Nanosheets Material for High-Performance Supercapacitors.

The remarkable electrochemical performance of graphene-based materials has drawn a tremendous amount of attention for their application in supercapacitors. Inspired by supramolecular chemistry, the supramolecular hydrogel is prepared by linking β-cyclodextrin to graphene oxide (GO). The carbon nanoparticles-anchored graphene nanosheets are then assembled after the hydrothermal reduction and carbonization of the supramolecular hydrogels; here, the β-cyclodextrin is carbonized to carbon nanoparticles that are uniformly anchored on the graphene nanosheets.

MicroRNA-93 inhibits ischemia-reperfusion induced cardiomyocyte apoptosis by targeting PTEN.

MicroRNAs have been implicated in some biological and pathological processes, including the myocardial ischemia/reperfusion (I/R) injury. Recent findings demonstrated that miR-93 might provide a potential cardioprotective effect on ischemic heart disease. This study was to investigate the role of miR-93 in I/R-induced cardiomyocyte injury and the potential mechanism.

All-Trans Retinoic Acid Attenuates Hypoxia-Induced Injury in NRK52E Cells via Inhibiting NF-x03BA;B/VEGF and TGF-β2/VEGF Pathway.

Background/aims: Hypoxia has recently been proposed as one of the most important factors in progressive renal injury. Hypoxia-induced vascular endothelial growth factor (VEGF) expression may play a critical role in maintaining peritubular capillary endothelium in renal disease. This study was designed to investigate the effect and underlying mechanism of all-trans retinoic acid (ATRA) on hypoxia-induced injury in NRK52E cells.

CRISPR-Cas9 for medical genetic screens: applications and future perspectives.

CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR associated nuclease 9) systems have emerged as versatile and convenient (epi)genome editing tools and have become an important player in medical genetic research. CRISPR-Cas9 and its variants such as catalytically inactivated Cas9 (dead Cas9, dCas9) and scaffold-incorporating single guide sgRNA (scRNA) have been applied in various genomic screen studies. CRISPR screens enable high-throughput interrogation of gene functions in health and diseases.

Preconditioning with PEP-1-SOD1 fusion protein attenuates ischemia/reperfusion-induced ventricular arrhythmia in isolated rat hearts.

PEP 1-Cu/Zn superoxide dismutase (PEP-1-SOD1) fusion protein preconditioning has been reported to protect the myocardium from ischemia/reperfusion (I/R)-induced injury by decreasing the infarct size, reducing levels of cardiomyocyte apoptosis and reducing the release of myocardial-specific biomarkers. The aim of the present study was to examine the effects of PEP-1-SOD1 pretreatment on I/R-induced ventricular arrhythmias in Langendorff-perfused rat hearts. The isolated rat hearts were pretreated with PEP-1-SOD1 prior to I/R, and the I/R-induced hemodynamic parameters, infarct size and ventricular arrhythmias were then assessed.

The Cardioprotective Effect of Icariin on Ischemia-Reperfusion Injury in Isolated Rat Heart: Potential Involvement of the PI3K-Akt Signaling Pathway.

Aims: Icariin (ICA), a flavonoid isolated from epimedii, has been reported to have potential protective effects on the cardiovascular system. This study is to investigate the effect and the underlying mechanisms of ICA on ischemia/reperfusion (I/R) injury.

Methods: Wister rat hearts were subjected to I/R using Langendorff perfusion system.

Pseudogene in cancer: real functions and promising signature.

Pseudogenes were initially regarded as non-functional genomic fossils resulted from inactivating gene mutations during evolution. However, later studies revealed that they play a plethora of roles at multiple levels (DNA, RNA and/or protein) in diverse physiological and pathological processes, especially in cancer, both parental-gene-dependently and parental-gene-independently. Pseudogenes can interact with parental genes or other gene loci, leading to alteration in their sequences and/or transcriptional activities.

Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway.

Nuclear factor-E2-related factor 2 (Nrf2) is an important cytoprotective transcription factor which plays a key role in antioxidant and detoxification processes. Recent studies have reported that development of chemoresistance is associated with the constitutive activation of the Nrf2-mediated signaling pathway in many types of cancer cells. Here, we investigated whether Nrf2 was associated with drug resistant in doxorubicin resistant BEL-7402 (BEL-7402/ADM) cells, and if chrysin could reverse drug resistance in BEL-7402/ADM cells.

Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway.

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox- sensitive transcription factor regulating expression of a number of cytoprotective genes. Recently, Nrf2 has emerged as an important contributor to chemoresistance in cancer therapy. In the present study, we found that non-toxic dose of apigenin (APG) significantly sensitizes doxorubicin-resistant BEL-7402 (BEL-7402/ADM) cells to doxorubicin (ADM) and increases intracellular concentration of ADM.

[Therapeutic effect of indole-3-carbinol on pig serum-induced hepatic fibrosis in rats].

This study is to investigate the therapeutic effect and mechanism of indole-3-carbinol (I3C) on pig serum-induced liver fibrosis of rats. The liver fibrotic model of rats was induced by pig serum. After models were successfully established, rats in the treatment groups were administered with I3C through intraperitoneal injection or curcumin by intragastric administration, daily for 17 days.

Indole-3-carbinol enhances the resolution of rat liver fibrosis and stimulates hepatic stellate cell apoptosis by blocking the inhibitor of κB kinase α/inhibitor of κB-α/nuclear factor-κB pathway.

Hepatic stellate cells (HSC) play a pivotal role in liver fibrosis, and the clearance of activated HSC by apoptosis is associated with the resolution of liver fibrosis. The development of strategies that promote this process in a selective way is therefore important. We evaluated the effects of indole-3-carbinol (I3C), a nutritional component derived from vegetables from the Brassica family, on liver fibrosis and HSC apoptosis.

Two-dimensional self-assembly of a porphyrin-polypyridyl ruthenium(II) hybrid on hopg surface through metal-ligand interactions.

The synthesis and self-assembly behavior of porphyrin-polypyridyl ruthenium(II) hybrid, which consists of a flexible alkyl chain attached with two conjugated moieties is described. The electronic absorption spectrum and emission spectra show that the [C(8)-TPP-(ip)Ru(phen)(2)](ClO(4))(2), abbreviated as (C(8)ip)TPPC has optical properties. Scanning tunneling microscopy (STM) studies found that the pi-pi interaction and metal-ligand interaction allow (C(8)ip)TPPC to form self-assembled structure and have an edge-on orientation on the highly oriented pyrolytic graphite (HOPG) surface.

Reducing reaction of Fe3O4 in nanoscopic reactors of a-CNTs.

A reduction of Fe3O4 nanowires in nanoscopic reactors of amorphous C:H nanotubes (a-CNTs) was taken to understand features of the chemical reaction mechanism in nanoscale reactors. Fe3O4 nanowires encapsulated in a-CNTs were reduced into iron at a relatively low temperature of 570 degrees C, producing iron nanoparticles encapsulated in CNTs accompanied by the crystallization of the a-CNT shell. It was found that carbon in the a-CNT shell rather than hydrogen (5.

Reduction features of NO over a potassium-doped C12A7-O- catalyst.

The NO reduction features over a noble-metal-free NO(x) storage/reduction catalyst ([Ca24Al28O64](4+*)4O-/K, defined as C12A7-O-/K), including the NO conversion, the N2 selectivity, and sulfur tolerance, were investigated with hydrogen and C3H6 as the reducing agents in a fixed-bed continuous flow reactor. The NO conversion and the N2 selectivity on the C12A7-O-/K catalyst mainly depends on the sample temperature, the percentage of potassium, the reducing agents, and the composition of the mixture of gases. The C12A7-O-/10%K catalyst possessed the highest selective reduction ability (to N2) among the catalysts C12A7-O-/x%K.