Platinum(IV)-Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models.

New heterometallic binuclear and trinuclear platinum(IV)-gold(I) compounds of the type [Pt(L) Cl (OH){(OOC-4-C H -PPh )AuCl} ] (L=NH , n=2; x=1, 2; L=diaminocyclohexane, DACH, n=1; x=2) are described. These compounds are cytotoxic and selective against a small panel of renal, bladder, ovarian, and breast cancer cell lines. We selected a trinuclear PtAu compound containing the Pt core based on oxaliplatin, to further investigate its cell-death pathway, cell and organelle uptake and anticancer effects against the triple-negative breast cancer (TNBC) MDA-MB-231 cell line.

Incidence of endophthalmitis following intravitreal anti VEGF injections at a tertiary care hospital in Pakistan.

Objective: To assess the rate of infectious endophthalmitis with anti-vascular endothelial growth factor injection, and to evaluate institutional procedure protocol in this regard.

Methods: The retrospective consecutive case series was conducted at Shifa International Hospital, Islamabad, Pakistan, from August 2018 to January 2019, and comprised 5-year data from August 2014 to July 2019 related to patients who underwent intravitreal anti-vascular endothelial growth factor injections. Data was analysed using SPSS 21.

Evaluation of practices of macular ganglion cell complex scan in early detection of glaucoma.

The purpose of this survey was to evaluate the level of awareness and practices regarding macular ganglion cell complex (GCC) scans for early detection of glaucoma. The study design was descriptive cross-sectional and the sampling technique was non-probability convenient method. Data was collected through an online survey, from 100 practicing ophthalmologists and optometrists of Pakistan in two weeks, from January 20 to February 03 2019.