Enhancement of 5-Fluorouracil Drug Delivery in a Graphene Oxide Containing Electrospun Chitosan/Polyvinylpyrrolidone Construct.

Electrospun nanofibrous mats, consisting of chitosan (CS) and polyvinylpyrrolidone (PVP), were constructed with the addition of graphene oxide (GO) for enhancement of delivery of the 5-Fluorouracil (5-Fu) chemotherapy drug. Upon studying the range of GO concentrations in CS/PVP, the concentration of 0.2% / GO was chosen for inclusion in the drug delivery model.

Biomedical Applications of Electrospun Graphene Oxide.

Graphene oxide (GO) has broad potential in the biomedical sector. The oxygen-abundant nature of GO means the material is hydrophilic and readily dispersible in water. GO has also been known to improve cell proliferation, drug loading, and antimicrobial properties of composites.

Ternary Metal Chalcogenide Heterostructure (AgInS-TiO) Nanocomposites for Visible Light Photocatalytic Applications.

Hybrid nanoarchitectures of AgInS and TiO photocatalysts were prepared by using a modified sol-gel method. The experimental results reveal that these nanocomposites display enhanced visible light absorption and effective charge carrier separation compared to their pristine parent samples (AgInS or TiO). 0.

Toxicity of Nanomaterials: Exposure, Pathways, Assessment, and Recent Advances.

Growth in production of manufactured goods and the use of nanomaterials in consumer products has mounted in the past few decades. Nanotoxicology or toxicity assessment of these engineered products is required to understand possible adverse effects and their fate inside the human body. The present review is a one stop assessment intended to be a state of the art understanding on nanotoxicity.

Fibrin-lipoplex system for controlled topical delivery of multiple genes.

Nonviral gene delivery via natural biomacromolecules show great promise as controlled release systems while avoiding the associated drawbacks with viral gene delivery such as immunogenicity and safety issues. Here, a fibrin-lipoplex system for topical delivery of multiple genes is described. In vitro release analysis showed efficient retention of the lipoplexes in the fibrin scaffold.

Fibrin as a delivery system for therapeutic drugs and biomolecules.

Fibrin is a natural biopolymer involved in the coagulation cascade. It acts as a reservoir for growth factors, cells, and enzymes during wound healing and provides a scaffold for the synthesis of extracellular matrix. Thus, the use of fibrin has expanded in recent years from traditional use as a sealant for surgical applications, to a tissue engineering scaffold capable of providing nature's cues for tissue regeneration.

Assessment of wound healing in the alloxan-induced diabetic rabbit ear model.

The enhancement of diabetic wound healing represents a major clinical challenge to researchers. The challenge faced is to identify a suitable animal model that best represents the human situation. However, the majority of diabetic wound healing models are in rodents and are hindered by rapid contraction and thus do not reflect epithelial cell migration, as seen in the human wound.

Fibrin scaffold promotes adenoviral gene transfer and controlled vector delivery.

Gene therapy using adenoviral vectors in tissue regeneration is hindered by a short duration of transgene expression. It is hypothesized that a fibrin scaffold will enhance delivery of the adenovirus to a wound site, precluding the need for high repeated doses. It was aimed to analyze whether fibrin could deliver a low single dose of viral vector to a wound site, without compromising transfection efficiency.

The use of therapeutic gene eNOS delivered via a fibrin scaffold enhances wound healing in a compromised wound model.

Diabetic healing is marked by a reduced nitric oxide (NO) production at the wound site. This study aimed to investigate whether a fibrin scaffold would enhance the delivery of adenovirus encoding endothelial nitric oxide synthase (eNOS), one of the enzymes responsible for NO production, resulting in more NO production, and enhanced healing. An alloxan rabbit ear ulcer model was used to investigate healing, in response to the following treatments: fibrin containing AdeNOS, AdeNOS alone, fibrin alone and no treatment.

Stereological methods to assess tissue response for tissue-engineered scaffolds.

The stereological approach can provide an objective unbiased assessment of structural change in biological systems. In this review, we elucidate the basic principles of stereology and their implementation in the analysis of tissue response to tissue-engineering scaffolds. A brief outline of tissue response parameters that can be estimated using stereological approach is included.

Optimization of a fibrin scaffold for sustained release of an adenoviral gene vector.

One of the major limitations of adenovirus as an efficient gene delivery vehicle is its transient nature of transgene expression. At present, no biodegradable release system exists that permits the sustained release of gene delivery. This study aimed to optimize a biodegradable fibrin scaffold for sustained adenoviral mediated gene delivery.