Publications by authors named "Ailin Han"
Individuals lack the ability to accurately detect emotional piloerection.
Psychophysiology
September 2024
Piloerection (e.g., goosebumps) is an essential thermoregulatory and social signaling mechanism in non-human animals.
View Article and Find Full Text PDFSevere COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine production, viral RNA and a sustained interferon (IFN) response, all of which are recapitulated and required for pathology in the SARS-CoV-2-infected MISTRG6-hACE2 humanized mouse model of COVID-19, which has a human immune system. Blocking either viral replication with remdesivir or the downstream IFN-stimulated cascade with anti-IFNAR2 antibodies in vivo in the chronic stages of disease attenuates the overactive immune inflammatory response, especially inflammatory macrophages. Here we show that SARS-CoV-2 infection and replication in lung-resident human macrophages is a critical driver of disease.
View Article and Find Full Text PDFArticle Synopsis
- - Severe COVID-19 involves ongoing lung inflammation and an overactive immune response, which can be studied in a specialized mouse model that mimics human immune system reactions to SARS-CoV-2 infection.
- - Treatments like Remdesivir and anti-IFNAR2 can help reduce this excessive immune response, particularly affecting inflammatory macrophages linked to the disease's severity.
- - Human macrophages play a key role in disease progression by activating inflammasomes that trigger inflammation and cell death (pyroptosis), which, while harmful, also helps limit SARS-CoV-2 viral replication.