is Key to a Prognostic Multigene Signature and a Potential Therapeutic Target in Acute Myeloid Leukemia.

As a rate-limiting enzyme for the serine biosynthesis pathway (SSP) in the initial step, phosphoglycerate dehydrogenase () is overexpressed in many different tumors, and pharmacological or genetic inhibition of promotes antitumor effects. In the present research, by analyzing several acute myeloid leukemia (AML) datasets in the Gene Expression Omnibus (GEO), we identified prognosis-related genes and constructed a multigene signature by univariate, multivariate Cox regression and LASSO regression. Subsequently, the multigene signature was confirmed through Cox, Kaplan-Meier, and ROC analyses in the validation cohort.

Environmental Kuznets curve for biodiversity loss: evidence from South and Southeast Asian countries.

This study aims to explore the income-biodiversity loss nexus in South and Southeast Asian countries covering the period between 2013 and 2019. Negative Binomial regression models are used to deal with the count regressand variable with specific emphasis on different taxonomic groups of threatened species, namely, mammal, bird, reptile, amphibian, fish, mollusk, other invertebrate, plant, and total threatened species. We find strong support of an inverted U-shaped relationship between income and biodiversity loss in all taxonomic groups of threatened species examined.

Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory.

Memory is stored in neural networks via changes in synaptic strength mediated in part by NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). Here we show that a cholecystokinin (CCK)-B receptor (CCKBR) antagonist blocks high-frequency stimulation-induced neocortical LTP, whereas local infusion of CCK induces LTP. CCK mice lacked neocortical LTP and showed deficits in a cue-cue associative learning paradigm; and administration of CCK rescued associative learning deficits.