Publications by authors named "Aileen-Diane Bamford"
The mammalian intestine is one of the most rapidly self-renewing tissues, driven by stem cells residing at the crypt bottom. Paneth cells form a major element of the niche microenvironment providing various growth factors to orchestrate intestinal stem cell homeostasis, such as Wnt3. Different Wnt ligands can selectively activate β-catenin-dependent (canonical) or -independent (noncanonical) signaling.
View Article and Find Full Text PDFAdult stem cells constantly react to local changes to ensure tissue homeostasis. In the main body of the stomach, chief cells produce digestive enzymes; however, upon injury, they undergo rapid proliferation for prompt tissue regeneration. Here, we identified p57 (p57) as a molecular switch for the reserve stem cell state of chief cells in mice.
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- Atorvastatin (ATV) is a cholesterol-lowering drug crucial for preventing cardiovascular deaths, and this study aims to identify genetic factors affecting its metabolism among individuals.
- A clinical trial with 60 healthy Mexican men evaluated ATV levels after a single dose, revealing four metabolizer phenotypes: slow, intermediate, normal, and fast.
- Six genetic polymorphisms were found to significantly impact ATV pharmacokinetics, with SLCO1B1 and ABCB1 variants playing a key role in the metabolism of the drug, highlighting the genetic basis for variability in drug responses.*