Greenland Norse walrus exploitation deep into the Arctic.

Walrus ivory was a prized commodity in medieval Europe and was supplied by Norse intermediaries who expanded across the North Atlantic, establishing settlements in Iceland and Greenland. However, the precise sources of the traded ivory have long remained unclear, raising important questions about the sustainability of commercial walrus harvesting, the extent to which Greenland Norse were able to continue mounting their own long-range hunting expeditions, and the degree to which they relied on trading ivory with the various Arctic Indigenous peoples that they were starting to encounter. We use high-resolution genomic sourcing methods to track walrus artifacts back to specific hunting grounds, demonstrating that Greenland Norse obtained ivory from High Arctic waters, especially the North Water Polynya, and possibly from the interior Canadian Arctic.

Electronic Health Record-Based Screening for Intimate Partner Violence: A Cluster Randomized Clinical Trial.

Importance: Intimate partner violence (IPV) is a significant public health issue, with a 25% lifetime prevalence. Screening for IPV in primary care is a recommended practice whose effectiveness is debated.

Objective: To assess the effect of an electronic health record (EHR)-based multifactorial intervention screening on the detection of IPV risk in primary care practice.

A systematic review and meta-analysis of neuroimaging studies examining synaptic density in individuals with psychotic spectrum disorders.

Background: Psychotic disorders have long been considered neurodevelopmental disorders where excessive synaptic pruning and cortical volume loss are central to disease pathology. We conducted a systematic review of the literature to identify neuroimaging studies specifically examining synaptic density across the psychosis spectrum.

Methods: PRISMA guidelines on reporting were followed.

Dissolved organic carbon diminishes manganese oxide-driven oxidation of chromium.

Oxidation of chromium (Cr)-bearing minerals by manganese (Mn) oxides is viewed as the dominant mechanism controlling geogenic production of Cr(VI) and its contamination of groundwater. This process may be modulated by other chemical constituents found in the natural environment, but such confounding factors have not been quantified. Here, we evaluated the mechanism of Cr(III) oxidation by mixed-valence Mn oxide in the presence of citric and gallic acids, two natural organic matter (NOM) constituents commonly found in the soil environment.

Small Community Water Systems Have the Highest Prevalence of Mn in Drinking Water in California, USA.

Manganese (Mn) is currently regulated as a secondary contaminant in California, USA; however, recent revisions of the World Health Organization drinking water guidelines have increased regulatory attention of Mn in drinking water due to increasing reports of neurotoxic effects in infants and children. In this study, Mn concentrations reported to California's Safe Drinking Water Information System were used to estimate the potentially exposed population within California based on system size. We estimate that between 2011 and 2021, over 525,000 users in areas with reported Mn data are potentially exposed to Mn concentrations exceeding the WHO health-based guideline (80 μg L), and over 34,000 users are potentially exposed to Mn concentrations exceeding the U.

An Unlikely Guest With an Overstayed Welcome: -Induced Postinfectious Irritable Bowel Syndrome.

Introduction: Postinfectious irritable bowel syndrome is a phenomenon that can occur following bouts of acute gastroenteritis. While bacterial pathogens are typically implicated in the development of postinfectious irritable bowel syndrome, viral and parasitic infections should also be considered as inciting pathogens.

Case Presentation: An immunocompetent, 65-year-old woman presented with several weeks of watery diarrhea, which polymerase chain reaction testing confirmed to be a Cyclospora infection.

Disparities in Drinking Water Manganese Concentrations in Domestic Wells and Community Water Systems in the Central Valley, CA, USA.

Over 1.3 million Californians rely on unmonitored domestic wells. Existing probability estimates of groundwater Mn concentrations, population estimates, and sociodemographic data were integrated with spatial data delineating domestic well communities (DWCs) to predict the probability of high Mn concentrations in extracted groundwater within DWCs in California's Central Valley.

A New Smartphone-Based Optic Nerve Head Biometric for Verification and Change Detection.

Purpose: Lens adapted smartphones are being used regularly instead of ophthalmoscopes. The most common causes of preventable blindness in the world, which are glaucoma and diabetic retinopathy, can develop asymptomatic changes to the optic nerve head (ONH) especially in the developing world where there is a dire shortage of ophthalmologists but ubiquitous mobile phones. We developed a proof-of-concept ONH biometric (application [APP]) to use as a routine biometric on a mobile phone.

Manganese, Arsenic, and Carbonate Interactions in Model Oxic Groundwater Systems.

Manganese and arsenic both threaten groundwater quality globally, but their chemical behavior leads to both co-contamination and separation of these contaminants from individual well to regional scales. Here we tested manganese and arsenic retention under conditions commonly found within aquifer redox fluctuating and transition zones where both arsenic and iron phases are present in oxidized forms, but manganese persists as reduced and soluble Mn(II). Analysis of column aqueous breakthrough data and characterization of solid-phase products using X-ray photoelectron (XPS) and absorption spectroscopies (XAS) show that the addition of bicarbonate increased manganese retention but decreased arsenic retention, while the presence of manganese and arsenic together increased both arsenic and manganese retention.

Performance of the RACE Score for the Prehospital Identification of Large Vessel Occlusion Stroke in a Suburban/Rural EMS Service.

: Emergency Medical Services (EMS) providers may identify and preferentially transport patients experiencing large vessel occlusion (LVO) stroke to appropriate treatment centers. The Rapid Arterial oCclusion Evaluation (RACE) scale was created for prehospital LVO detection, yet few studies have evaluated its function in real-world EMS settings. Our objective was to assess the prehospital performance of the RACE scale for detecting LVO stroke following implementation at a large suburban/rural agency in the United States.

Emergency Medical Services Simple Thoracostomy for Traumatic Cardiac Arrest: Postimplementation Experience in a Ground-based Suburban/Rural Emergency Medical Services Agency.

Background: Tube thoracostomy has long been the standard of care for treatment of tension pneumothorax in the hospital setting yet is uncommon in prehospital care apart from helicopter emergency medical services.

Objective: We aimed to evaluate the performance of simple thoracostomy (ST) for patients with traumatic cardiac arrest and suspected tension pneumothorax.

Methods: We conducted a retrospective case series of consecutive patients with traumatic cardiac arrest where simple thoracostomy was used during the resuscitation effort.

Prospective, Randomized Comparison of the Effect of Two Antimicrobial Regimes on Surgical Site Infection Rate in Dogs Undergoing Orthopedic Implant Surgery.

Objectives: To determine whether extending prophylactic antimicrobial administration into the postoperative period would decrease the surgical site infection (SSI) rate in clean canine orthopedic surgery associated with a metal implant.

Study Design: Randomized prospective clinical study.

Sample Population: Consecutive procedures (n = 400) on dogs that had clean orthopedic surgery using a metal implant.

Are the fabellae bisected by the femoral cortices in a true craniocaudal pelvic limb radiograph?

Objectives: To assess whether the bisection of the fabellae by their respective femoral cortices is a useful criterion for assessing positioning of craniocaudal pelvic limb radiographs, and whether this is consistent in limbs affected or unaffected by medial patella luxation.

Methods: Computed tomography multi-planar reconstructions were used to determine the relative positions of the fabellae with respect to the femoral cortices.

Results: Only 36% of fabellae overall were bisected by the femoral cortex.

What is the value and impact of the safety World Conference? Evaluators' reflections of safety 2012.

Using survey and documentary information collected as part of an evaluation of the 2012 conference, this paper reflects upon the value of the 2012 World Conference to attendees of the event. The results are discussed in the context of questions about what the purpose of conference is to the world injury prevention community and how they are organised. The evaluators challenge the community and future organisers to clarify what the purpose of these events are to better inform future evaluation activities.

Heart rate at rest, exercise capacity, and mortality risk in veterans.

Heart rate (HR) at rest has been associated inversely with mortality risk. However, fitness is inversely associated with mortality risk and both increased fitness and β-blockade therapy affect HR at rest. Thus, both fitness and β-blockade therapy should be considered when HR at rest-mortality risk association is assessed.

Avascular necrosis of the canine radial carpal bone: a condition analogous to Preiser's disease?

An eight-year-old male neutered Staffordshire bull terrier was presented for investigation of right forelimb lameness of 14 months' duration. Radiography showed mottled osteolysis of the right radial carpal bone. Histopathology of the bone demonstrated replacement of healthy bone with granulation tissue suggestive of ischaemic necrosis.

Cystic fibrosis transmembrane conductance regulator recruitment to phagosomes in neutrophils.

Optimal microbicidal activity of human polymorphonuclear leukocytes (PMN) relies on the generation of toxic agents such as hypochlorous acid (HOCl) in phagosomes. HOCl formation requires H2O2 produced by the NADPH oxidase, myeloperoxidase derived from azurophilic granules, and chloride ion. Chloride transport from cytoplasm into phagosomes requires chloride channels which include cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-activated chloride channel.

Chloride transport in functionally active phagosomes isolated from Human neutrophils.

Chloride anion is critical for hypochlorous acid (HOCl) production and microbial killing in neutrophil phagosomes. However, the molecular mechanism by which this anion is transported to the organelle is poorly understood. In this report, membrane-enclosed and functionally active phagosomes were isolated from human neutrophils by using opsonized paramagnetic latex microspheres and a rapid magnetic separation method.

Designing photoswitchable peptides using the AsLOV2 domain.

Photocontrol of functional peptides is a powerful tool for spatial and temporal control of cell signaling events. We show that the genetically encoded light-sensitive LOV2 domain of Avena Sativa phototropin 1 (AsLOV2) can be used to reversibly photomodulate the affinity of peptides for their binding partners. Sequence analysis and molecular modeling were used to embed two peptides into the Jα helix of the AsLOV2 domain while maintaining AsLOV2 structure in the dark but allowing for binding to effector proteins when the Jα helix unfolds in the light.

Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells.

The cAMP-dependent signaling pathways that orchestrate dendritic cell (DC) maturation remain to be defined in detail. Although cAMP was previously thought to signal exclusively through protein kinase A (PKA), it is now clear that cAMP also activates exchange protein activated by cAMP (Epac), a second major cAMP effector. Whether cAMP signaling via PKA is sufficient to drive DC maturation or whether Epac plays a role has not been examined.

Electron hydration and ion-electron pairs in water clusters containing trivalent metal ions.

The hydrated electron is one of the most fundamental nucleophiles in aqueous solution, yet it is a transient species in liquid water, making it challenging to study. The solvation thermodynamics of the electron are important for determining the band structure and properties of water and aqueous solutions. However, a wide range of values for the electron solvation enthalpy (-1.

Doxorubicin-induced cardiac toxicity and cardiac rest gated blood pool imaging.

Anthracyclines are one of the most commonly used and potent chemotherapeutic agents. Doxorubicin (Adriamycin) is one common anthracycline used to treat many solid tumors including breast, sarcomas, gynecologic and hematological malignancies, such as leukemias and lymphomas. However, its use is often limited due to dose-dependent cardiotoxicity.