Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: cohort study of 151 141 singleton pregnancies.

Objectives: To identify any associations between in utero exposure to five over-the-counter (non-prescription) analgesics (paracetamol, ibuprofen, aspirin, diclofenac, naproxen) and adverse neonatal outcomes.

Design: Retrospective cohort study using the Aberdeen Maternity and Neonatal Databank.

Participants: 151 141 singleton pregnancies between 1985 and 2015.

Over-the-counter analgesics during pregnancy: a comprehensive review of global prevalence and offspring safety.

Background: Analgesia during pregnancy is often necessary. Due to their widespread availability, many mothers opt to use over-the-counter (OTC) analgesics. Those analgesic compounds and their metabolites can readily cross the placenta and reach the developing foetus.

Expression of the Insulin-like Growth Factor System in First- and Second-Trimester Human Embryonic and Fetal Gonads.

Context: Insulin-like growth factor (IGF) signaling is crucial for sex differentiation and development of Leydig and Sertoli cells in fetal mice testes. No such information is available for human embryonic and fetal testes and ovaries.

Objective: To investigate presence and activity of the IGF signaling system during human embryonic and fetal ovarian and testicular development.