Publications by authors named "Aijiao Xiao"
Ryanodine receptors (RyR) located on the membrane of the endoplasmic reticulum (ER), are a potent regulator of intracellular calcium levels upon activation. Dysregulated Ca homeostasis is characteristic of hypoxic-ischemic (HI) brain injury and ultimately leads to neurodegeneration. RyRs have thereby been implicated in the Ca imbalance that occurs during and after HI.
View Article and Find Full Text PDF[Therapeutic effects of moxibustion on neonatal mice with hypoxia-ischemia brain injury].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
September 2021
Article Synopsis
- The study included 106 ICR mice, divided into three groups: sham (normal), model (hypoxia-ischemia), and moxibustion-treated.
- Results showed moxibustion improved behavioral performance and reduced brain damage compared to the model group, alongside increased SOD2 protein expression and decreased MDA levels, indicating potential protective effects.
Article Synopsis
- The study investigates the impact of moxibustion treatment on learning and memory in neonatal mice with hypoxic-ischemic encephalopathy (HIE), focusing on the expression of proteins associated with neural function.
- It involved creating a HIE model in mice and then applying moxibustion therapy, observing brain tissue changes, protein expressions, and memory performance through tests like the Morris maze.
- Results indicated that moxibustion reduced brain injury, increased important neuronal proteins (pCaMKⅡα and NeuN), and improved learning and memory capabilities compared to the untreated HIE model group.
Article Synopsis
- Heat-sensitive suspended moxibustion is shown to provide neuroprotection against focal cerebral ischemia/reperfusion injury, but the mechanisms behind this effect are not well understood.
- In an experiment with rats, researchers investigated the effects of 15- and 35-minute sessions of suspended moxibustion on cerebral injury, with various assays used to assess injury and cell death.
- Results indicated that the 35-minute moxibustion significantly reduced infarct volume and neuronal apoptosis, with improved expression of protective proteins compared to the 15-minute treatment.
Article Synopsis
- The NA-1 inhibitor disconnects NMDA glutamate receptors from harmful signaling pathways, preserving their normal function while reducing neurotoxic effects.
- In a study using a neonatal hypoxic-ischemic brain injury model, NA-1 was administered to mouse pups either before or after artery occlusion, showing a significant reduction in brain damage (infarct volume) and improved behavioral outcomes.
- The findings suggest that NA-1 could be an effective treatment for minimizing damage from neonatal strokes and may be a potential therapeutic option for neonatal stroke prevention or treatment.
Background: Our previous study found that suppression of TRPM7 reduced neuronal death in adult rat ischemic brain injury. It was reported that carvacrol blocked TRPM7 and attenuated brain injury in an adult rat MCAO model. The effects of carvacrol on neonatal stroke remain unknown.
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- Neonatal hypoxic-ischemic encephalopathy leads to brain injury and motor dysfunction, prompting the need for effective treatments.
- Xyloketal B, a compound derived from a mangrove fungus, shows promise by reducing neuron death and improving recovery in mouse models of brain injury caused by lack of oxygen and glucose.
- The compound works by decreasing harmful calcium entry and influencing important proteins related to cell survival, suggesting its potential as a therapeutic option for brain injury in neonates.
Neonatal hypoxic-ischemic brain injury and its related illness hypoxic-ischemic encephalopathy (HIE) are major causes of nervous system damage and neurological morbidity in children. Hypoxic preconditioning (HPC) is known to be neuroprotective in cerebral ischemic brain injury. K(ATP) channels are involved in ischemic preconditioning in the heart; however the involvement of neuronal K(ATP) channels in HPC in the brain has not been fully investigated.
View Article and Find Full Text PDFHeat-sensitive moxibustion has neuroprotective effects against focal cerebral ischemia/reperfusion injury, however its mechanism of action remains unclear. In this study, rat models of focal cerebral ischemia/reperfusion injury were treated with suspended moxibustion at acupoint Dazhui (DU14) for 35 minutes. Results showed that suspended moxibustion decreased infarct volume, reduced cortical myeloperoxidase activity, and suppressed serum levels of proinflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury.
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- The study examined how antisense c-myb oligodeoxynucleotides (ODNs) impact testosterone secretion induced by hCG in isolated rat Leydig cells.
- Results indicated that these ODNs decreased testosterone secretion in a dose-dependent manner and reduced c-Myb protein levels in the Leydig cells.
- Further tests highlighted that cAMP can enhance testosterone secretion, while calcium channel blockers and protein synthesis inhibitors negatively affected both c-Myb levels and testosterone secretion.