CGRdb2.0: A Python Database Management System for Molecules, Reactions, and Chemical Data.

This work introduces CGRdb2.0─an open-source database management system for molecules, reactions, and chemical data. CGRdb2.

Immunomodulatory effect of the combined use of Vetosporin Zh probiotic and Gumi-malysh biologically active additive.

Background And Aim: Various means and methods, including probiotics and biologically active additives, have been developed and proposed for production to increase the immunobiological reactivity of the body, regardless of the etiology of its decrease. This study aimed to find out the immune status of calves during the preweaning period in association with Vetosporin Zh, Normosil, and Gumi-malysh.

Materials And Methods: The research object was 30-day-old calves of black-and-white Holstein breed.

Correction: Kutlushina, A., et al. Ligand-Based Pharmacophore Modeling Using Novel 3D Pharmacophore Signatures. Molecules, 2018, 23, 3094.

The authors would like to add the funding number to the published article [...

Ligand-Based Pharmacophore Modeling Using Novel 3D Pharmacophore Signatures.

Pharmacophore modeling is a widely used strategy for finding new hit molecules. Since not all protein targets have available 3D structures, ligand-based approaches are still useful. Currently, there are just a few free ligand-based pharmacophore modeling tools, and these have a lot of restrictions, e.